{"id":"W4313681112","doi":"10.1016/j.mito.2023.01.001","title":"ER stress-associated transcription factor CREB3 is essential for normal Ca2+, ATP, and ROS homeostasis","year":2023,"lang":"en","type":"article","venue":"Mitochondrion","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Cell biology; Reactive oxygen species; Mitochondrion; Mitochondrial ROS; Oxidative stress; Endoplasmic reticulum; Unfolded protein response; Homeostasis; XBP1; Cytosol; Downregulation and upregulation; Biology; SOD2; Chemistry; Biochemistry; Superoxide dismutase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003792808,0.0001692963,0.0001455306,0.00005794282,0.0001441738,0.000054801,0.00008879317,0.0001822323,0.00004658705],"category_scores_gemma":[0.00005763594,0.0001638094,0.0001393985,0.0001022997,0.00005042447,0.00001006623,0.0000428563,0.00005907282,0.00001166092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001311772,"about_ca_system_score_gemma":0.00003435019,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004629229,"about_ca_topic_score_gemma":0.00007664651,"domain_scores_codex":[0.9989735,0.00002920707,0.0001784547,0.0003698661,0.000142908,0.0003060944],"domain_scores_gemma":[0.9995302,0.0000150702,0.00006308786,0.0001886752,0.00007479817,0.0001281529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002709172,0.0001080089,0.005686822,0.00008948813,0.0001007001,0.000006090135,0.0004104344,0.00004916986,0.9752744,0.00002725392,0.01397316,0.004003553],"study_design_scores_gemma":[0.003879246,0.0004930737,0.04277118,0.00007027806,0.0001467408,0.000004533873,0.0003676766,0.001489501,0.9101356,0.00007366442,0.03998001,0.0005885189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960425,0.0004792644,0.0009119163,0.0003092901,0.0003445331,0.0003471686,0.001444003,0.00004585605,0.00007543874],"genre_scores_gemma":[0.9955149,0.0005490733,0.00009443313,0.0001473351,0.0002176562,0.0000907905,0.001552437,0.00003068059,0.001802751],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06513882,"threshold_uncertainty_score":0.6679955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089952896618714,"score_gpt":0.2540407656956095,"score_spread":0.2431412367294224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}