{"id":"W4313681112","doi":"10.1016/j.mito.2023.01.001","title":"ER stress-associated transcription factor CREB3 is essential for normal Ca2+, ATP, and ROS homeostasis","year":2023,"lang":"en","type":"article","venue":"Mitochondrion","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs; Ontario Ministry of Agriculture, Food and Rural Affairs","keywords":"Cell biology; Reactive oxygen species; Mitochondrion; Mitochondrial ROS; Oxidative stress; Endoplasmic reticulum; Unfolded protein response; Homeostasis; XBP1; Cytosol; Downregulation and upregulation; Biology; SOD2; Chemistry; Biochemistry; Superoxide dismutase; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001674214,0.0004624967,0.000396444,0.0003212049,0.0004028895,0.0004376239,0.0004708697,0.0002914112,0.003266631],"category_scores_gemma":[0.000368838,0.0001722178,0.0003546522,0.0002521125,0.0004350264,0.0002888005,0.0004778454,0.0007548799,0.001349154],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006756426,"about_ca_system_score_gemma":0.0005981945,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002102964,"about_ca_topic_score_gemma":0.003640972,"domain_scores_codex":[0.9998299,0.00001317379,0.000009345679,0.0000359871,0.00005411245,0.00005757236],"domain_scores_gemma":[0.999684,0.00002636499,0.00007304933,0.00003864356,0.00007184142,0.0001061096],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003792605,0.00002014395,0.0003175077,0.0000527134,0.000006842721,0.00016096,0.00001293316,0.00003947441,0.9956326,0.0003042126,0.0004144715,0.002658858],"study_design_scores_gemma":[0.0001027844,0.0001585951,0.03679615,0.00003541656,0.00003634576,0.001802091,0.0001138849,0.002265916,0.9436334,0.000906763,0.01410989,0.00003878935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9546614,0.006817756,0.0206948,0.001165524,0.0005082113,0.0000951128,0.00510361,0.001740719,0.009212726],"genre_scores_gemma":[0.9832011,0.0009271058,0.00525163,0.0002550419,0.00005181134,0.00005240013,0.003386069,0.0002381513,0.006636663],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003266631,"threshold_uncertainty_score":0.01092798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01089952896618714,"score_gpt":0.2540407656956095,"score_spread":0.2431412367294224,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}