{"id":"W4313682025","doi":"10.1101/2023.01.02.522483","title":"Indoline CD4-mimetic Compounds Mediate Potent and Broad HIV-1 Inhibition and Sensitization to Antibody-dependent Cellular Cytotoxicity","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"National Institutes of Health; University of Pennsylvania","keywords":"Antibody-dependent cell-mediated cytotoxicity; Indoline; Gp41; Antibody; Cytotoxicity; Trimer; Chemistry; Virology; Cell biology; Biology; Biochemistry; Stereochemistry; In vitro; Epitope; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008029593,0.0003363983,0.000139517,0.0001885674,0.00009814048,0.0001352547,0.0002277317,0.0001470265,0.001813291],"category_scores_gemma":[0.00007990697,0.00009525719,0.0001115405,0.00009392343,0.0001018879,0.0001129412,0.0001338359,0.0002734154,0.0003028729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002374597,"about_ca_system_score_gemma":0.000123616,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003200099,"about_ca_topic_score_gemma":0.0007554617,"domain_scores_codex":[0.999931,0.00001312236,0.000004889541,0.00000976821,0.00001902354,0.00002217786],"domain_scores_gemma":[0.9999661,0.000006243073,0.000008597818,0.000003660717,0.000006569138,0.000008858628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002181031,0.0001634145,0.0001398087,0.00009827349,0.000008079991,0.00005619939,0.00001723233,0.000525835,0.9903097,0.0003499743,0.0002104337,0.007903093],"study_design_scores_gemma":[0.00006766093,0.001843255,0.0007338737,0.000007108974,0.00001003718,0.0001460714,0.000009352817,0.0008497534,0.9919493,0.00003468017,0.004343679,0.000005244514],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9875699,0.001992432,0.002775913,0.00007093132,0.00003055091,0.0001381213,0.000335185,0.0001278612,0.006959074],"genre_scores_gemma":[0.9936093,0.0008306386,0.002174793,0.00004895034,0.000009199935,0.00006113269,0.000326497,0.000008241139,0.002931197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001813291,"threshold_uncertainty_score":0.006066084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0148417606017842,"score_gpt":0.2381349933659525,"score_spread":0.2232932327641682,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}