{"id":"W4313702110","doi":"10.1093/jnci/djad001","title":"A polygenic two-hit hypothesis for prostate cancer","year":2023,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sinai Health System; Public Health Ontario; Lunenfeld-Tanenbaum Research Institute; Princess Margaret Cancer Centre; University of Toronto; University Health Network; Vector Institute; Ontario Institute for Cancer Research","funders":"Helse Sør-Øst RHF; Novo Nordisk Fonden; Norges Forskningsråd; Universitetet i Oslo; National Cancer Institute; National Institutes of Health; Cancer Research UK; Prostate Cancer Canada; Canadian Institutes of Health Research; Genome Canada; Movember Foundation","keywords":"Prostate cancer; Germline; Carcinogenesis; Germline mutation; Biology; Cancer; Oncology; Risk stratification; Somatic cell; Genetics; Medicine; Internal medicine; Gene; Mutation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001407014,0.0005615036,0.0006957614,0.001087694,0.0005924431,0.001094707,0.001001687,0.001084398,0.007052112],"category_scores_gemma":[0.005019001,0.0002601091,0.0007564851,0.0006930095,0.00157277,0.0008314418,0.0007370934,0.0007528651,0.0006822541],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004612496,"about_ca_system_score_gemma":0.0006420672,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003018456,"about_ca_topic_score_gemma":0.002279042,"domain_scores_codex":[0.9991405,0.0002942257,0.00002827325,0.000255551,0.0001346317,0.0001468948],"domain_scores_gemma":[0.9982815,0.0008814554,0.0002604911,0.0002188467,0.0001111219,0.0002465994],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001589042,0.0009644792,0.6092844,0.0004774482,0.001735399,0.007421172,0.001502512,0.02658729,0.01721048,0.2214901,0.01114803,0.1005897],"study_design_scores_gemma":[0.0005295206,0.001652786,0.4486291,0.000148166,0.001016851,0.01314405,0.0008337784,0.1703326,0.001919637,0.3533183,0.008295001,0.0001801347],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9048606,0.003204735,0.06500798,0.01104526,0.000197284,0.0002680918,0.0007993301,0.0003630309,0.01425368],"genre_scores_gemma":[0.9899765,0.000980364,0.00340566,0.001383814,0.000209868,0.0001145833,0.0003499101,0.00001841417,0.003561016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007052112,"threshold_uncertainty_score":0.0235917,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1353365169537812,"score_gpt":0.4222117836403943,"score_spread":0.2868752666866131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}