{"id":"W4313703408","doi":"10.1038/s41598-023-27486-7","title":"Deubiquitinase catalytic activity of MYSM1 is essential in vivo for hematopoiesis and immune cell development","year":2023,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; European Commission; Leukemia and Lymphoma Society of Canada; Canada Research Chairs; INFRAFRONTIER; McGill University","keywords":"Haematopoiesis; Cell biology; Biology; Immune system; Chromatin; In vivo; Knockout mouse; Bone marrow; Stem cell; Gene; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002268411,0.0003493983,0.000139387,0.0002541525,0.0001407127,0.0002971432,0.0002179333,0.0001905579,0.001253186],"category_scores_gemma":[0.0001427763,0.0001259632,0.0001294768,0.0001254101,0.0003119013,0.0001801882,0.0003085277,0.0003152854,0.0003934914],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002271137,"about_ca_system_score_gemma":0.0001715344,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819189,"about_ca_topic_score_gemma":0.0003069862,"domain_scores_codex":[0.9998324,0.00002421967,0.0000226961,0.0000462038,0.00004687849,0.00002765219],"domain_scores_gemma":[0.9998016,0.00002113484,0.00007415494,0.00002803674,0.00001520768,0.00005987426],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005015033,0.000008625325,0.0005669834,0.00001817522,0.00000282153,0.00005742245,0.000003992649,0.00003459744,0.9981093,0.0002721333,0.00002343062,0.0008522958],"study_design_scores_gemma":[0.000008666931,0.00007439229,0.009247416,0.000004687692,0.00001258617,0.0007297648,0.00001583652,0.0006586383,0.9860474,0.0001447705,0.003052337,0.000003369335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908343,0.001593772,0.005335831,0.00008482322,0.00002796402,0.000009373404,0.0005192969,0.0001004226,0.001494168],"genre_scores_gemma":[0.9955665,0.0003822384,0.001821816,0.0000227226,0.000004861894,0.00001079821,0.0004517217,0.00002194834,0.00171734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001253186,"threshold_uncertainty_score":0.004192352,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01306061571466085,"score_gpt":0.2512564980698904,"score_spread":0.2381958823552296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}