{"id":"W4313706744","doi":"10.1126/sciimmunol.adf0244","title":"Evading the Toll booth: How “silent” flagellins may bind yet fail to activate TLR5","year":2023,"lang":"en","type":"letter","venue":"Science Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; BC Children's Hospital","funders":"Crohn's and Colitis Canada","keywords":"TLR5; Flagellin; Biology; Toll-like receptor; Gut microbiome; Toll; Immune system; Function (biology); Receptor; Cell biology; Microbiome; Microbiology; Immunology; Innate immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.001965384,0.0006262331,0.0007368367,0.001317822,0.001582755,0.0002870718,0.003022416,0.001601644,0.0005238019],"category_scores_gemma":[0.00105703,0.0004546223,0.0002650374,0.001504016,0.002574296,0.0005098186,0.0009317886,0.00320079,0.01303946],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003646861,"about_ca_system_score_gemma":0.0007068245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002118703,"about_ca_topic_score_gemma":0.00002394657,"domain_scores_codex":[0.9951795,0.0008645802,0.0005942049,0.00118687,0.0002472397,0.001927618],"domain_scores_gemma":[0.9965654,0.001022825,0.0004638365,0.001665506,0.0002496384,0.00003280113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009214834,0.000009606953,0.00001282751,0.00001393378,0.0001531355,0.00005034158,0.0008821659,0.000004809661,0.564836,0.0001560616,0.4294991,0.004289868],"study_design_scores_gemma":[0.0003533106,0.0002518244,0.0006086773,0.00009948646,0.0000483591,0.0001500641,0.0005822662,0.000003568879,0.2202479,0.0001411812,0.7770633,0.0004501492],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.1609448,0.001672799,0.00009877421,0.8190001,0.01477696,0.001220187,0.00005708062,0.0004028473,0.001826411],"genre_scores_gemma":[0.3196031,0.001849526,0.0001277257,0.3093648,0.002197988,0.0007712322,0.001202549,0.0003835046,0.3644995],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.5096353,"threshold_uncertainty_score":0.9997905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751980719390081,"score_gpt":0.2660318638624906,"score_spread":0.2385120566685897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}