{"id":"W4313706744","doi":"10.1126/sciimmunol.adf0244","title":"Evading the Toll booth: How “silent” flagellins may bind yet fail to activate TLR5","year":2023,"lang":"en","type":"letter","venue":"Science Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity; BC Children's Hospital","funders":"Crohn's and Colitis Canada","keywords":"TLR5; Flagellin; Biology; Toll-like receptor; Gut microbiome; Toll; Immune system; Function (biology); Receptor; Cell biology; Microbiome; Microbiology; Immunology; Innate immune system; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002475972,0.0007710555,0.0009259855,0.0003342777,0.001458766,0.002164446,0.001004056,0.01829735,0.002927897],"category_scores_gemma":[0.01228207,0.0004196209,0.0008042085,0.0001997028,0.003036084,0.003235262,0.0009235347,0.02620818,0.004057763],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002254746,"about_ca_system_score_gemma":0.00103137,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001340625,"about_ca_topic_score_gemma":0.00133402,"domain_scores_codex":[0.9986145,0.0005317247,0.0001212442,0.0001909557,0.0003599356,0.0001815468],"domain_scores_gemma":[0.9958166,0.002689383,0.0002066856,0.0002463314,0.0005729129,0.000468036],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003790735,0.0001050442,0.001085027,0.0001225966,0.0000428206,0.007349628,0.0002159513,0.0001808721,0.003675033,0.01094655,0.9414423,0.03445526],"study_design_scores_gemma":[0.0005094053,0.0004153112,0.002284052,0.000293186,0.00006035165,0.01498872,0.0007754422,0.001677737,0.00447229,0.05249702,0.9219009,0.0001254999],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.002334602,0.004505699,0.0005446018,0.9458954,0.04347854,0.00001515262,0.00003501071,0.0000785982,0.003112391],"genre_scores_gemma":[0.02136363,0.004217603,0.0006027961,0.8924224,0.07290005,0.00003600111,0.00002856714,0.0000403126,0.008388681],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.01829735,"threshold_uncertainty_score":0.01635933,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02751980719390081,"score_gpt":0.2660318638624906,"score_spread":0.2385120566685897,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}