{"id":"W4313814066","doi":"10.20944/preprints202301.0139.v1","title":"Recent Trends in Antisense Therapies for Duchenne muscular dystrophy","year":2023,"lang":"en","type":"preprint","venue":"Preprints.org","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Muscular Dystrophy Canada; Alberta Innovates; Alberta Innovates - Health Solutions; Women and Children's Health Research Institute; Children's Health Research Institute","keywords":"Duchenne muscular dystrophy; Antisense therapy; Exon skipping; Muscular dystrophy; Medicine; Disease; Clinical trial; Genetic enhancement; Dystrophin; Bioinformatics; Exon; Gene; Biology; Genetics; Internal medicine; Alternative splicing","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001672949,0.0007869937,0.0009241611,0.001109437,0.0002285548,0.001345946,0.000521299,0.001193601,0.003983581],"category_scores_gemma":[0.001308614,0.0003192635,0.0006815997,0.00081633,0.0006424246,0.001524024,0.0007500866,0.002442936,0.002409727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006034715,"about_ca_system_score_gemma":0.0006913774,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002775227,"about_ca_topic_score_gemma":0.0005141424,"domain_scores_codex":[0.9995133,0.000120318,0.00004809686,0.00009404549,0.0001746347,0.00004957749],"domain_scores_gemma":[0.9992375,0.0004097705,0.00006988453,0.00002880739,0.0001813234,0.00007263057],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004549925,0.000317799,0.0005161403,0.0113257,0.0001676092,0.0005109548,0.0003346698,0.001468165,0.05177767,0.02876186,0.04143117,0.8629332],"study_design_scores_gemma":[0.00006184285,0.0007185725,0.0006271591,0.001108544,0.0001345353,0.0009267004,0.00009967144,0.0006230965,0.0167729,0.007793963,0.9710923,0.00004070556],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002170146,0.9793723,0.007742546,0.002775544,0.001022451,0.00004005254,0.0001091777,0.0001451997,0.006622581],"genre_scores_gemma":[0.00980768,0.9761054,0.005642259,0.002071002,0.001306949,0.00008388673,0.0002843174,0.0000584018,0.004640089],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003983581,"threshold_uncertainty_score":0.01332641,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1353912280836743,"score_gpt":0.3615361751009483,"score_spread":0.2261449470172741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}