{"id":"W4313816740","doi":"10.1097/ypg.0000000000000331","title":"Mediating effect of genome-wide DNA methylation on suicidal ideation induced by stressful events","year":2022,"lang":"en","type":"article","venue":"Psychiatric Genetics","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Suicidal ideation; DNA methylation; Genome; Methylation; Psychology; Genetics; Biology; DNA; Clinical psychology; Medicine; Computational biology; Gene; Poison control; Suicide prevention; Medical emergency; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006459547,0.0002098663,0.000205185,0.0001441088,0.0001894865,0.0000103086,0.0002385574,0.0001263579,0.00003231795],"category_scores_gemma":[0.0001350653,0.0002211776,0.0001192275,0.0003174496,0.00001552949,0.00000271772,0.0001272114,0.0001621749,0.000003685428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004058289,"about_ca_system_score_gemma":0.000059549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001929859,"about_ca_topic_score_gemma":0.00000730188,"domain_scores_codex":[0.9980392,0.0003832699,0.0004606428,0.000399786,0.0004712761,0.0002458106],"domain_scores_gemma":[0.9990067,0.00009369579,0.0003686341,0.0003797146,0.0000718001,0.00007944601],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001489997,0.0001205427,0.1063589,0.00003710912,0.00005825573,2.079502e-7,0.00006659565,0.01040922,0.8753398,0.000008362439,0.0001404231,0.007311577],"study_design_scores_gemma":[0.001501389,0.004104728,0.07306606,0.000002763416,0.00009729669,6.6668e-7,0.00005647166,0.0006562028,0.9172238,0.0002512024,0.002686798,0.0003526069],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936641,0.003017716,0.001766245,0.00007886647,0.0005281625,0.0004317649,0.0001037109,0.00001168439,0.0003977412],"genre_scores_gemma":[0.9979278,0.0002476377,0.0004450154,0.00006099127,0.000210403,0.00006091175,0.0009478269,0.00004066526,0.00005878143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04188399,"threshold_uncertainty_score":0.9019361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007835435982626291,"score_gpt":0.2599401557640394,"score_spread":0.2521047197814131,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}