{"id":"W4313829039","doi":"10.3390/biomedicines11010169","title":"Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Epigenetics; Immunotherapy; Immune system; Carcinogenesis; Epigenetic therapy; Cancer; Cancer immunotherapy; Medicine; Cancer research; Epigenesis; Immunology; Bioinformatics; Biology; DNA methylation; Genetics; Internal medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005106011,0.0004459639,0.001004877,0.0002958142,0.0001115331,0.00002287282,0.0004480935,0.0005190756,0.00002690195],"category_scores_gemma":[0.0002241631,0.0003505977,0.0004469616,0.0003890933,0.0001396844,0.000001500407,0.0001233323,0.0001601383,0.00004770884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008643602,"about_ca_system_score_gemma":0.0005515564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007658155,"about_ca_topic_score_gemma":0.00002433535,"domain_scores_codex":[0.9977589,0.0001098469,0.0006068203,0.0006967349,0.0002822179,0.0005454483],"domain_scores_gemma":[0.9989032,0.00007860615,0.0002570849,0.0004886391,0.0001514809,0.0001209738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003478048,0.00004262435,2.289486e-7,0.01423945,0.0005719368,0.00001096934,0.00003670201,0.000001192949,0.05930427,0.00001802305,0.0613295,0.8644103],"study_design_scores_gemma":[0.0003325546,0.0002841413,1.172367e-7,0.003650881,0.0001489218,0.000008210372,0.00002195252,0.000007911424,0.002302422,0.00003073024,0.9928469,0.0003652378],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001847384,0.9947146,0.002089312,0.00007900388,0.001122817,0.001598517,0.0002707191,0.00008709864,0.0000194401],"genre_scores_gemma":[0.000002361059,0.9891291,0.0006002681,0.00006461881,0.002442402,0.001976084,0.00127693,0.0003208306,0.004187439],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9315174,"threshold_uncertainty_score":0.9998946,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06545465584488153,"score_gpt":0.4120408639443578,"score_spread":0.3465862080994763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}