{"id":"W4313829039","doi":"10.3390/biomedicines11010169","title":"Targeting Epigenetic Mechanisms: A Boon for Cancer Immunotherapy","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"","keywords":"Epigenetics; Immunotherapy; Immune system; Carcinogenesis; Epigenetic therapy; Cancer; Cancer immunotherapy; Medicine; Cancer research; Epigenesis; Immunology; Bioinformatics; Biology; DNA methylation; Genetics; Internal medicine; Gene expression; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005070072,0.0005691894,0.0008656048,0.001211895,0.0002859353,0.0009070059,0.0005897827,0.001184717,0.00442234],"category_scores_gemma":[0.000424549,0.0002058923,0.0004273706,0.000943377,0.0005878508,0.001530644,0.0006815552,0.002615551,0.002283069],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007158813,"about_ca_system_score_gemma":0.0009034627,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000479536,"about_ca_topic_score_gemma":0.00123548,"domain_scores_codex":[0.9998631,0.00002833739,0.00001169495,0.00002324005,0.00005385642,0.00001964323],"domain_scores_gemma":[0.9998208,0.00008346121,0.00001603837,0.00000778524,0.00004713162,0.00002486378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009200023,0.00009753919,0.0001972173,0.009049659,0.00007575589,0.0003051059,0.00008602058,0.0003864505,0.009509632,0.01722685,0.0511227,0.9118511],"study_design_scores_gemma":[0.00001396168,0.00008028173,0.0003163036,0.0009373144,0.00003812504,0.0006362603,0.00003825999,0.0000965174,0.001196247,0.004105997,0.9925288,0.00001197583],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001819088,0.9957216,0.0004266989,0.001417093,0.0005324797,0.000005315862,0.00001951878,0.00001611668,0.001679228],"genre_scores_gemma":[0.001486838,0.9952793,0.0004037741,0.0007976388,0.0004548601,0.00000930026,0.00003757188,0.000003387363,0.001527433],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00442234,"threshold_uncertainty_score":0.01479417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06545465584488153,"score_gpt":0.4120408639443578,"score_spread":0.3465862080994763,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}