{"id":"W4313855464","doi":"10.22541/au.167330741.18394805/v1","title":"Impaired thymic AIRE expression underlies autoantibodies against type I IFNs in humans with inborn errors of the alternative NF-kB pathway","year":2023,"lang":"en","type":"preprint","venue":"","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto; SickKids Foundation; University of Manitoba","funders":"NHLBI Division of Intramural Research; National Center for Advancing Translational Sciences; Honjo International Scholarship Foundation; Science for Life Laboratory; Howard Hughes Medical Institute; Georgia Clinical and Translational Science Alliance; Vetenskapsrådet; National Cancer Institute; Knut och Alice Wallenbergs Stiftelse; Fondation pour la Recherche Médicale; European Commission; Assistance Publique - Hôpitaux de Paris; Bundesministerium für Bildung und Forschung; Else Kröner-Fresenius-Stiftung; Institut des maladies génétiques Imagine; Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation; Institut National de la Santé et de la Recherche Médicale; Fondation du Souffle; Division of Intramural Research, National Institute of Allergy and Infectious Diseases; Göran Gustafssons Stiftelser; St. Giles Foundation; National Institutes of Health; Fisher Center for Alzheimer's Research Foundation; Agence Nationale de la Recherche; National Institute of Allergy and Infectious Diseases","keywords":"Autoantibody; Immunology; Biology; Medicine; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001412076,0.0004612199,0.0003413066,0.000554702,0.0002024162,0.0004242547,0.0001639208,0.0005443884,0.002418785],"category_scores_gemma":[0.0005457035,0.0002069927,0.0001868905,0.0001629055,0.0005351163,0.0002086265,0.0003140608,0.0005422576,0.0003372101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001104878,"about_ca_system_score_gemma":0.00006835687,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002243267,"about_ca_topic_score_gemma":0.0001701288,"domain_scores_codex":[0.9998817,0.00002296206,0.00001063006,0.00004006984,0.00002438115,0.00002010688],"domain_scores_gemma":[0.9996909,0.00007141265,0.0001327136,0.00004212511,0.00001511416,0.00004769637],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002972899,0.0001193187,0.1455416,0.0001902215,0.0001701365,0.0152394,0.0004595817,0.0002707949,0.8173412,0.001323836,0.000977982,0.01539296],"study_design_scores_gemma":[0.0001624396,0.0005430647,0.7289934,0.0001006644,0.0003814505,0.1041692,0.0006939396,0.001718913,0.1537582,0.003875379,0.00557119,0.00003222922],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962714,0.0008993537,0.001341299,0.0001541593,0.00002469413,0.000005052789,0.000208568,0.00005528114,0.00104011],"genre_scores_gemma":[0.9988595,0.0002100267,0.0003048457,0.00004201713,0.00003307206,0.00000349609,0.0001021541,0.00001833311,0.0004265337],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002418785,"threshold_uncertainty_score":0.008091629,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02668404916663455,"score_gpt":0.2543076795472241,"score_spread":0.2276236303805895,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}