{"id":"W4313856768","doi":"10.1016/j.jbc.2023.102891","title":"Influenza virus and pneumococcal neuraminidases enhance catalysis by similar yet distinct sialic acid–binding strategies","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Influenza Virus Research Studies","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Novo Nordisk Fonden; Stockholms Universitet; Vetenskapsrådet; Novo Nordisk; Carl Tryggers Stiftelse för Vetenskaplig Forskning","keywords":"Sialic acid; Neuraminidase; Fetuin; Biochemistry; Glycoprotein; Enzyme; Chemistry; Virus; Streptococcus pneumoniae; Hemagglutinin (influenza); Neuraminic acid; Influenza A virus; Glycosylation; Microbiology; Bacteria; N-Acetylneuraminic acid; Lectin; Biology; Virology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002820981,0.0005045119,0.000298563,0.0001616466,0.000120255,0.0004001243,0.0002749565,0.0003659752,0.0004773305],"category_scores_gemma":[0.000256026,0.0002154242,0.0004103465,0.000153175,0.0002146383,0.0003327695,0.0003700594,0.0003697093,0.0002090236],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003134694,"about_ca_system_score_gemma":0.0001932172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005984882,"about_ca_topic_score_gemma":0.0009356653,"domain_scores_codex":[0.9997165,0.0000531081,0.0000282211,0.00004064428,0.00009258676,0.00006897532],"domain_scores_gemma":[0.999877,0.00002222897,0.00003228865,0.0000172076,0.0000209945,0.00003033371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005214745,0.00000980389,0.0002586202,0.00001647393,0.000006056232,0.00001861396,0.00001129573,0.0000329091,0.9988589,0.00006332431,0.000005673574,0.0006662387],"study_design_scores_gemma":[0.000009986376,0.0001782235,0.006197745,0.00000302068,0.00001367948,0.0002318586,0.00002257386,0.0006453719,0.9918634,0.00004683542,0.0007818713,0.000005527163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959986,0.001016658,0.001635549,0.00002375354,0.000008216893,0.00001704451,0.00005432674,0.00001612803,0.00122973],"genre_scores_gemma":[0.9960653,0.0004066103,0.002396913,0.0000216273,0.000004408866,0.00001801914,0.0001554616,0.00000842291,0.000923335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005984882,"threshold_uncertainty_score":0.002274454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08127040749613895,"score_gpt":0.3843178804064821,"score_spread":0.3030474729103432,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}