{"id":"W4313856862","doi":"10.1016/j.jbc.2023.102893","title":"SPECC1L binds the myosin phosphatase complex MYPT1/PP1β and can regulate its distribution between microtubules and filamentous actin","year":2023,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Microtubule and mitosis dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation; Ottawa Hospital Research Institute; Canadian Institutes of Health Research; University of Ottawa","keywords":"Microtubule; Myosin; Actin; Phosphatase; Protein phosphatase 1; Cell biology; Cytoskeleton; Biology; Chemistry; Biophysics; Biochemistry; Phosphorylation; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001641823,0.0007284897,0.0004909776,0.0003881649,0.0005061074,0.0003989945,0.0003843194,0.0004785647,0.002375975],"category_scores_gemma":[0.0002736656,0.0002110367,0.0004705294,0.0003962574,0.0002882124,0.0002411512,0.0006175752,0.000772525,0.001502567],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001287666,"about_ca_system_score_gemma":0.000345208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001596718,"about_ca_topic_score_gemma":0.002139193,"domain_scores_codex":[0.9996192,0.00003697064,0.00001492684,0.0001132747,0.0001282178,0.00008740261],"domain_scores_gemma":[0.9998351,0.00001723545,0.00005125642,0.00001683733,0.00003298326,0.00004652006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004852634,0.000022662,0.0008492267,0.00008238401,0.00001186451,0.000132079,0.00001707086,0.00007240465,0.9959592,0.0001142061,0.0002647505,0.002425645],"study_design_scores_gemma":[0.00001469367,0.0001152392,0.01545687,0.0000184074,0.00001661033,0.001072609,0.00003379516,0.002409594,0.9701746,0.00007207778,0.01060058,0.00001482163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9686279,0.01043188,0.01186513,0.0005285384,0.00008140243,0.00008986081,0.001917085,0.0003002434,0.006158017],"genre_scores_gemma":[0.9820487,0.00180553,0.005140972,0.0003722982,0.00003329619,0.0001230588,0.004878838,0.00006324963,0.0055341],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375975,"threshold_uncertainty_score":0.00934273,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02638297629783598,"score_gpt":0.2592953406812645,"score_spread":0.2329123643834285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}