{"id":"W4313887350","doi":"10.1053/j.gastro.2022.12.042","title":"Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis","year":2023,"lang":"en","type":"article","venue":"Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Mount Sinai Hospital","funders":"National Institutes of Health; Crohn's and Colitis Canada; Ferring Pharmaceuticals; Genentech; Canadian Association of Gastroenterology; Canadian Institutes of Health Research; Leona M. and Harry B. Helmsley Charitable Trust; Regeneron Pharmaceuticals; National Cancer Institute; Kenneth Rainin Foundation; Pfizer; National Institute of Diabetes and Digestive and Kidney Diseases; Amgen","keywords":"Ulcerative colitis; Autoantibody; Biomarker; Integrin; Medicine; Cancer research; Pathology; Immunology; Chemistry; Antibody; Internal medicine; Biochemistry; Receptor; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003765043,0.0005487739,0.0004085684,0.00152401,0.0002753831,0.001130941,0.0003155891,0.001192316,0.001647569],"category_scores_gemma":[0.00197343,0.0002218532,0.0003449365,0.0006736522,0.0002020865,0.0005174643,0.0002482339,0.0006137874,0.0007138831],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002105979,"about_ca_system_score_gemma":0.0001153341,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000405541,"about_ca_topic_score_gemma":0.0003984647,"domain_scores_codex":[0.9995998,0.00009101892,0.00004082179,0.00006533047,0.0001126887,0.00009030379],"domain_scores_gemma":[0.9990854,0.0002416589,0.0002695658,0.00006721923,0.0001722614,0.0001639716],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001866392,0.0001657697,0.8393596,0.0001791014,0.0001755388,0.01212899,0.0002148688,0.0002425246,0.1012404,0.0004661427,0.001542483,0.04241812],"study_design_scores_gemma":[0.00005671843,0.0009567714,0.9083779,0.000155228,0.000213854,0.05293349,0.0004680246,0.002094813,0.02427499,0.0007680838,0.009668298,0.00003185332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841704,0.006156863,0.001204242,0.0004067742,0.0001929459,0.00002419692,0.000325032,0.0001235526,0.007395909],"genre_scores_gemma":[0.99718,0.0007731928,0.0009344068,0.0001338373,0.0001231522,0.000005876595,0.0002439778,0.00001248302,0.0005930497],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001647569,"threshold_uncertainty_score":0.005511642,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0207107348632463,"score_gpt":0.2613804906628906,"score_spread":0.2406697557996443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}