{"id":"W4313887583","doi":"10.21203/rs.3.rs-2394919/v1","title":"Synergistic inter-clonal cooperation involving crosstalk, co-option and co-dependency can enhance the invasiveness of genetically distant cancer clones","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cell Image Analysis Techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of New Brunswick","funders":"China Scholarship Council; New Brunswick Innovation Foundation","keywords":"Biology; Crosstalk; Phenotype; Autocrine signalling; Metastasis; Cancer cell; Genetic heterogeneity; Paracrine signalling; Cancer; Cancer research; clone (Java method); Somatic evolution in cancer; Genetics; Cell culture; Gene; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002364981,0.0002976464,0.0003331349,0.0002538459,0.0002473645,0.0006339372,0.000281209,0.0003777542,0.001655396],"category_scores_gemma":[0.0002607437,0.0001578653,0.0003702971,0.0001835977,0.0002371086,0.0003289453,0.0006451175,0.0007727017,0.0004031803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002206284,"about_ca_system_score_gemma":0.0001989758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000352588,"about_ca_topic_score_gemma":0.0009116647,"domain_scores_codex":[0.9995666,0.00009635305,0.00002925876,0.00007766864,0.0001364055,0.0000936482],"domain_scores_gemma":[0.9995797,0.000121574,0.00007946377,0.00007651262,0.00006166423,0.000081124],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005312333,0.00005482816,0.0008676899,0.00005056809,0.000009933821,0.000144155,0.00004088558,0.0001388898,0.9962005,0.0002399864,0.00007141024,0.002128075],"study_design_scores_gemma":[0.00002301759,0.0007232275,0.01973202,0.00002304103,0.00007856719,0.00109336,0.0002283306,0.007365785,0.9626403,0.0003221479,0.007744689,0.00002537016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910314,0.001216742,0.0048808,0.00009834493,0.00002981401,0.00003354935,0.00008770836,0.00005066266,0.002571062],"genre_scores_gemma":[0.9954495,0.0002790752,0.002251372,0.00006077399,0.000009121902,0.00003329831,0.0000884413,0.00000951917,0.00181886],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001655396,"threshold_uncertainty_score":0.005537868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04949923106519948,"score_gpt":0.425571252234778,"score_spread":0.3760720211695785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}