{"id":"W4313890401","doi":"10.3390/cancers15020418","title":"Multicenter International Study of the Consensus Immunoscore for the Prediction of Relapse and Survival in Early-Stage Colon Cancer","year":2023,"lang":"en","type":"article","venue":"Cancers","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"National Cancer Institute; Ministry of Education, Culture, Sports, Science and Technology; Society for Immunotherapy of Cancer; Neuroendocrine Tumor Research Foundation","keywords":"Medicine; Internal medicine; Stage (stratigraphy); Microsatellite instability; Oncology; Colorectal cancer; Clinical endpoint; Cohort; Proportional hazards model; Cancer; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000215206,0.00005988818,0.0001272948,0.00005018644,0.00003897459,0.000003852836,0.0000840834,0.00003144699,0.00002423409],"category_scores_gemma":[0.00004999281,0.00003607539,0.00004696384,0.0001957725,0.0001444522,0.0000161191,0.00002922774,0.00007763187,1.224275e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002694481,"about_ca_system_score_gemma":0.0001624969,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007113003,"about_ca_topic_score_gemma":0.003414789,"domain_scores_codex":[0.9994063,0.00002993683,0.000210498,0.0001088865,0.0001559914,0.00008842616],"domain_scores_gemma":[0.9994991,0.00015514,0.0001110559,0.0001498882,0.00007274384,0.00001203113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008216926,0.00006938499,0.9525091,0.00009367714,0.0005048711,0.000002267287,0.007508907,0.000631046,0.02671447,0.00001125675,0.001376788,0.002361281],"study_design_scores_gemma":[0.006987688,0.0003235278,0.9775776,0.0001504713,0.00006817673,6.388074e-7,0.007109888,0.002970134,0.001743524,0.000002475041,0.003031108,0.00003472422],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964494,0.0003542788,0.000001854044,0.0006383192,0.001323762,0.0009710118,0.0001881387,0.000008739355,0.00006454585],"genre_scores_gemma":[0.9984876,0.000544978,0.000003288115,0.00005396944,0.00004354757,0.0001329474,0.000004547488,0.000008666564,0.0007204741],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02506852,"threshold_uncertainty_score":0.9994987,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03738400144067851,"score_gpt":0.3194965974571014,"score_spread":0.2821125960164229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}