{"id":"W4313891170","doi":"10.3390/ijms24021243","title":"The Role of Myeloperoxidase in Clozapine-Induced Inflammation: A Mechanistic Update for Idiosyncratic Drug-Induced Agranulocytosis","year":2023,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Pfizer","keywords":"Clozapine; Myeloperoxidase; Pharmacology; Medicine; Inflammation; Immunology; Bone marrow; Schizophrenia (object-oriented programming)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001334001,0.001088086,0.001360714,0.001355985,0.0004880462,0.002016405,0.000956062,0.001843542,0.001230682],"category_scores_gemma":[0.0005312638,0.0004004293,0.0006406753,0.0007550256,0.002226076,0.003203748,0.001352936,0.005011784,0.0005120595],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009497236,"about_ca_system_score_gemma":0.001165431,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005860598,"about_ca_topic_score_gemma":0.00104681,"domain_scores_codex":[0.9996728,0.00006903298,0.00006612172,0.00005538419,0.00007231476,0.00006434274],"domain_scores_gemma":[0.9993027,0.0002383565,0.0001201834,0.0000471731,0.0001973649,0.00009408408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.001766905,0.001034205,0.004535884,0.01796497,0.0004184197,0.008644152,0.001430914,0.001657573,0.107418,0.04247417,0.03262118,0.7800336],"study_design_scores_gemma":[0.0001857847,0.001772669,0.007937006,0.002906369,0.0005917026,0.009333675,0.0009093693,0.002529272,0.02376442,0.01975235,0.9301775,0.000139865],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.007612227,0.9792666,0.002425321,0.00738301,0.001145156,0.00002733386,0.00005447372,0.00005629581,0.002029621],"genre_scores_gemma":[0.03691736,0.9513835,0.002259427,0.00256547,0.004964006,0.00005326333,0.00008555564,0.00001554056,0.001755946],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002016405,"threshold_uncertainty_score":0.007054925,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01600827528009615,"score_gpt":0.2759215716057133,"score_spread":0.2599132963256172,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}