{"id":"W4313893438","doi":"10.1038/s41591-022-02128-z","title":"Autologous T cell therapy for MAGE-A4+ solid cancers in HLA-A*02+ patients: a phase 1 trial","year":2023,"lang":"en","type":"article","venue":"Nature Medicine","topic":"CAR-T cell therapy research","field":"Medicine","cited_by":194,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"National Center for Advancing Translational Sciences; Sylvester Comprehensive Cancer Center, University of Miami Health Systems; Cancer Prevention and Research Institute of Texas; University of Texas MD Anderson Cancer Center; Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute; National Cancer Institute; National Institutes of Health","keywords":"Medicine; Internal medicine; Oncology; Cancer; Antigen; Response Evaluation Criteria in Solid Tumors; Clinical endpoint; Immunotherapy; Melanoma; Clinical trial; Gastroenterology; Phases of clinical research; Immunology; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001149653,0.0003249542,0.000871575,0.0007678071,0.00008325572,0.00001134081,0.0002700047,0.0005574269,0.002133848],"category_scores_gemma":[0.0009314258,0.0002326591,0.0001778365,0.001397016,0.0002181909,0.00005898586,0.00004307694,0.001372754,0.00004226551],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000493238,"about_ca_system_score_gemma":0.0004586483,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001970112,"about_ca_topic_score_gemma":0.00009325284,"domain_scores_codex":[0.9969451,0.000117031,0.0005676384,0.000596504,0.0009716997,0.0008020581],"domain_scores_gemma":[0.9981458,0.0005663226,0.0001330195,0.0005507687,0.0003205735,0.0002835619],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2710537,0.002041513,0.001993301,0.0004598192,0.0002935168,0.0005564765,0.003751772,0.00001702188,0.1340002,0.00006026006,0.282746,0.3030264],"study_design_scores_gemma":[0.592022,0.02072341,0.00307097,0.0003279444,0.0001036696,0.00001358901,0.000522522,0.001281744,0.02200849,0.0003145283,0.3592241,0.0003869696],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9756999,0.002810865,0.00003009106,0.008837905,0.002355966,0.005251089,0.00006739343,0.00023594,0.004710827],"genre_scores_gemma":[0.9732702,0.001795422,0.0001241573,0.004267628,0.002682527,0.0006470549,0.0007262313,0.0001183738,0.01636844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3209683,"threshold_uncertainty_score":0.9987783,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03360066020318397,"score_gpt":0.4150260083184507,"score_spread":0.3814253481152667,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}