{"id":"W4313895381","doi":"10.1038/s41537-022-00330-z","title":"Gray matter volume drives the brain age gap in schizophrenia: a SHAP study","year":2023,"lang":"en","type":"article","venue":"Schizophrenia","topic":"Functional Brain Connectivity Studies","field":"Neuroscience","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute; Centre for Global Health Research; Lawson Health Research Institute; St. Michael's Hospital; Centre for Addiction and Mental Health; University of British Columbia; St. Joseph’s Healthcare Hamilton; Baycrest Hospital; University of Calgary; McMaster University; Robarts Clinical Trials; University of Toronto; Western University; University Health Network; Occupational Cancer Research Centre; Queen's University","funders":"U.S. National Library of Medicine; National Center for Research Resources; National Institute of Dental and Craniofacial Research; National Institute on Drug Abuse; Fonds de Recherche du Québec - Santé; Compute Canada; Canadian Institutes of Health Research; National Institutes of Health; Government of Ontario; U.S. Department of Energy; University of Minnesota; McGill University; National Institute of Mental Health; Ontario Brain Institute; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Massachusetts General Hospital","keywords":"Neuroimaging; Schizophrenia (object-oriented programming); Brain size; Psychology; Gray (unit); Neuroscience; Medicine; Psychiatry; Magnetic resonance imaging; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.001011903,0.0004237326,0.0004438104,0.0005085139,0.000698883,0.0002345417,0.0008854218,0.00009579008,0.0002916559],"category_scores_gemma":[0.005344388,0.0003171778,0.0001703724,0.002421932,0.0004138616,0.0003570779,0.0007352591,0.0007117135,0.006328141],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008743043,"about_ca_system_score_gemma":0.00008151471,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001351013,"about_ca_topic_score_gemma":0.001284394,"domain_scores_codex":[0.9960158,0.0007618602,0.0004669756,0.001194791,0.0007863641,0.0007741424],"domain_scores_gemma":[0.9942667,0.00457594,0.0001269055,0.0008847123,0.0000406691,0.0001050953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"observational","study_design_scores_codex":[0.003704446,0.001683858,0.2578383,0.0001031073,0.0001997309,0.002489269,0.0127524,0.0008841282,0.09191791,0.01004699,0.6095036,0.008876332],"study_design_scores_gemma":[0.003924376,0.0003333421,0.9704723,0.00004870823,0.00002768448,0.00003845895,0.001319152,0.0007104278,0.001144345,0.01271452,0.008623119,0.0006435369],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624313,0.00004911098,0.00001271553,0.03263819,0.001000493,0.001098563,0.00003737041,0.0004518444,0.002280488],"genre_scores_gemma":[0.9871179,0.000009762837,0.00006595811,0.005070166,0.000336741,0.0003891997,0.000005020502,0.0000712024,0.006934073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.712634,"threshold_uncertainty_score":0.9999281,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0392150460589494,"score_gpt":0.2811976542183532,"score_spread":0.2419826081594038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}