{"id":"W4313897443","doi":"10.1016/j.labinv.2022.100029","title":"Development of an Automated Capillary Immunoassay to Detect Prion Glycotypes in Creutzfeldt-Jakob Disease","year":2023,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa; University of Manitoba; Public Health Agency of Canada; Manitoba Health","funders":"Public Health Agency; Public Health Agency of Canada","keywords":"Blot; Genotyping; Genotype; Biology; Gene; Phenotype; Virology; Creutzfeldt-Jakob Syndrome; Disease; Prion protein; Pathology; Genetics; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000323673,0.0001143908,0.00009914735,0.0001262619,0.00006587258,0.00001789507,0.000135183,0.00008459743,0.000007964572],"category_scores_gemma":[0.0002097433,0.000123124,0.00002256192,0.0005380158,0.00003277065,0.00001392781,0.00007610919,0.00004389785,0.00002233505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003006898,"about_ca_system_score_gemma":0.0004275102,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001283934,"about_ca_topic_score_gemma":0.00006954406,"domain_scores_codex":[0.9990503,0.0001087783,0.0002629143,0.0002594404,0.0001475929,0.0001709443],"domain_scores_gemma":[0.9993553,0.000007004329,0.00007860562,0.0002628967,0.00009883833,0.0001973127],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008580922,0.00001362336,0.003183159,0.00004761376,0.00001141143,0.000005198944,0.0002389725,0.0007609346,0.9874241,0.00002295998,0.000220067,0.007986142],"study_design_scores_gemma":[0.0003382094,0.00008640972,0.1785492,0.00008563206,0.000007319669,2.82129e-7,0.0001068256,0.001377559,0.8081492,0.0001549891,0.010907,0.0002374134],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985486,0.0009072718,0.00004255726,0.00008444004,0.00007585272,0.0001997641,0.00002901598,0.000103714,0.00000878774],"genre_scores_gemma":[0.9950518,0.0001299932,0.00398589,0.0002445877,0.00004441926,0.00007061251,0.0004395222,0.00002032173,0.0000128704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1792749,"threshold_uncertainty_score":0.502085,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01226221608391631,"score_gpt":0.2762573757988643,"score_spread":0.263995159714948,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}