{"id":"W4315433294","doi":"10.21203/rs.3.rs-2352899/v1","title":"RTS,S/AS02A malaria vaccine-induced IgG responses equally recognize native-like fucosylated and non-fucosylated Plasmodium falciparum circumsporozoite proteins","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"University of Toronto","keywords":"Circumsporozoite protein; Plasmodium falciparum; Malaria; Virology; Malaria vaccine; Plasmodium (life cycle); Biology; Immunology; Computer science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000386887,0.0007996632,0.0003384884,0.0003143639,0.0001358853,0.0003889602,0.0003584325,0.000583539,0.004250948],"category_scores_gemma":[0.0004200241,0.0002100236,0.0004644801,0.0001523912,0.0002455874,0.0002964431,0.0002545616,0.001297815,0.001352337],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005049463,"about_ca_system_score_gemma":0.0002548917,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009757957,"about_ca_topic_score_gemma":0.0006187659,"domain_scores_codex":[0.9997467,0.00004109663,0.00001606895,0.00005779884,0.00004358207,0.00009467341],"domain_scores_gemma":[0.9997855,0.00006883348,0.00002997949,0.00003565674,0.00003709617,0.00004294326],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007686285,0.0001374071,0.0003165037,0.00005850476,0.00002503763,0.00005610092,0.0000257822,0.0001936781,0.9948601,0.0002290818,0.0004080184,0.002921135],"study_design_scores_gemma":[0.0001657495,0.00167457,0.006579985,0.00001556804,0.00007233094,0.0003354634,0.00006109102,0.002483841,0.9832086,0.0003100503,0.00508329,0.000009508462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886136,0.0005657062,0.003207262,0.0001854612,0.0001832603,0.0001133777,0.0006836809,0.0001492776,0.006298295],"genre_scores_gemma":[0.9887156,0.0002762832,0.00150017,0.0001673358,0.00006787149,0.00006639149,0.001382575,0.00006786152,0.007755889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004250948,"threshold_uncertainty_score":0.01422083,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07849482564541332,"score_gpt":0.3816016416619429,"score_spread":0.3031068160165296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}