{"id":"W4315435807","doi":"10.1096/fj.202201272r","title":"Acute activation of <scp>SERCA</scp> with <scp>CDN1163</scp> attenuates <scp>IgE</scp> ‐mediated mast cell activation through selective impairment of <scp>ROS</scp> and p38 signaling","year":2023,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Niagara; Brock University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Ontario Research Foundation","keywords":"SERCA; Degranulation; Cell biology; Mast cell; Chemistry; Endoplasmic reticulum; Proinflammatory cytokine; Immunoglobulin E; Signal transduction; Immunology; Inflammation; Biology; Biochemistry; ATPase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001572723,0.0005064028,0.0005209883,0.0001996299,0.000212137,0.0002810045,0.0002889817,0.0004165251,0.001814141],"category_scores_gemma":[0.0001313023,0.0001470767,0.0004542516,0.0002194339,0.0004002769,0.000238657,0.0002017667,0.001141826,0.0003497702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003544826,"about_ca_system_score_gemma":0.000438819,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059872,"about_ca_topic_score_gemma":0.00184801,"domain_scores_codex":[0.9997784,0.00002705498,0.00002753838,0.00003951777,0.00005264062,0.00007476605],"domain_scores_gemma":[0.9998989,0.00001212146,0.00002917385,0.00001180604,0.00001095585,0.00003702523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006333799,0.00009677612,0.00009564636,0.00006124614,0.000009226778,0.00005007462,0.000009330442,0.00004531728,0.9982615,0.00004428423,0.00007922891,0.0006139789],"study_design_scores_gemma":[0.0001084642,0.0008067935,0.003609341,0.000008591081,0.00002740725,0.000146156,0.00002694744,0.000735817,0.9928119,0.00002771043,0.001685738,0.000005163414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953371,0.001449246,0.001197011,0.0001879836,0.00007976337,0.00006619494,0.0006794865,0.0001425003,0.0008607149],"genre_scores_gemma":[0.9949017,0.000888872,0.001239644,0.000100743,0.0000270789,0.0001137112,0.0009172427,0.00001505338,0.001795924],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001814141,"threshold_uncertainty_score":0.006068885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127117313348832,"score_gpt":0.2180507891393859,"score_spread":0.2067796160058975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}