{"id":"W4315435807","doi":"10.1096/fj.202201272r","title":"Acute activation of <scp>SERCA</scp> with <scp>CDN1163</scp> attenuates <scp>IgE</scp> ‐mediated mast cell activation through selective impairment of <scp>ROS</scp> and p38 signaling","year":2023,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Mast cells and histamine","field":"Immunology and Microbiology","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Regional Municipality of Niagara; Brock University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Government of Canada; Ontario Research Foundation","keywords":"SERCA; Degranulation; Cell biology; Mast cell; Chemistry; Endoplasmic reticulum; Proinflammatory cytokine; Immunoglobulin E; Signal transduction; Immunology; Inflammation; Biology; Biochemistry; ATPase; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001293497,0.0007291325,0.001053451,0.0005488883,0.0009769492,0.0001168802,0.0006210484,0.0005636447,0.00004856318],"category_scores_gemma":[0.0007902108,0.0005402549,0.0002897081,0.00132102,0.0006727313,0.0006424978,0.0002500027,0.00146505,0.0001184875],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002091883,"about_ca_system_score_gemma":0.0003561922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001798907,"about_ca_topic_score_gemma":0.00002612689,"domain_scores_codex":[0.9958124,0.000665737,0.00117686,0.0006873478,0.0004279272,0.0012298],"domain_scores_gemma":[0.9926717,0.004024636,0.001898803,0.000507672,0.0007410482,0.0001560971],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006499304,0.0004322329,0.005357981,0.0001645959,0.001221769,0.00002467309,0.01495043,0.000594579,0.9628548,0.0001088425,0.01395636,0.0002687111],"study_design_scores_gemma":[0.00381392,0.001504593,0.01271728,0.0003234476,0.000494912,0.0002532663,0.02033079,0.0001699008,0.9547867,0.0004966194,0.005034642,0.00007392102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9939588,0.0008861534,0.00118389,0.0001421131,0.0004256549,0.0008203451,0.0002173564,0.0001363495,0.002229314],"genre_scores_gemma":[0.9908485,0.001191352,0.0003125558,0.0001766988,0.0002239416,0.00004727493,0.0004808154,0.0001140982,0.006604713],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008921715,"threshold_uncertainty_score":0.9997049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01127117313348832,"score_gpt":0.2180507891393859,"score_spread":0.2067796160058975,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}