{"id":"W4315474239","doi":"10.21203/rs.3.rs-2423179/v1","title":"The DACH1 gene is frequently deleted in prostate cancer, restrains prostatic intraepithelial neoplasia, decreases DNA damage repair, and predicts therapy responses.","year":2023,"lang":"en","type":"preprint","venue":"Research Square","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; BC Cancer Agency","funders":"Canada Research Chairs; Broad Institute; Thomas Jefferson University; Comprehensive Cancer Center, City of Hope","keywords":"Intraepithelial neoplasia; Prostate cancer; Cancer; Prostate; Medicine; High-grade prostatic intraepithelial neoplasia; Cancer research; Gene; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001603761,0.0002095667,0.0001657362,0.0004764455,0.0002050388,0.0002703234,0.00008532307,0.000200114,0.005720263],"category_scores_gemma":[0.0003016525,0.0001152257,0.0001105001,0.000394802,0.000202555,0.0001209341,0.0001696348,0.000367722,0.0006915205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003165525,"about_ca_system_score_gemma":0.0002294244,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008374606,"about_ca_topic_score_gemma":0.001272402,"domain_scores_codex":[0.9998703,0.00002247841,0.000004377581,0.00002835679,0.00005533146,0.00001908298],"domain_scores_gemma":[0.9998765,0.00002397553,0.00003829328,0.000008840508,0.00001445057,0.00003797702],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009874527,0.0001234115,0.09353414,0.0002981992,0.0001234285,0.001058677,0.00008768982,0.0005947496,0.8368101,0.001412702,0.003755528,0.06121395],"study_design_scores_gemma":[0.0000627777,0.0003769681,0.5814834,0.00003289265,0.0000877651,0.009576426,0.0001413393,0.001776071,0.3553645,0.001110648,0.04996952,0.00001778113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9759113,0.009720735,0.003066448,0.0006887067,0.0001357088,0.00002891701,0.003054016,0.0001755438,0.007218548],"genre_scores_gemma":[0.9838004,0.001844342,0.001226238,0.00007751744,0.00003943738,0.00001585636,0.002628256,0.00002312585,0.01034482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005720263,"threshold_uncertainty_score":0.01913619,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1004553444193858,"score_gpt":0.4219688880700647,"score_spread":0.3215135436506789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}