{"id":"W4315477044","doi":"10.56367/oag-037-10240","title":"Genomic instability and nuclear architecture in cancer","year":2023,"lang":"en","type":"article","venue":"Open Access Government","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; CancerCare Manitoba","funders":"","keywords":"Genome instability; Telomere; Cancer; Biology; Genome; Cancer cell; Cancer research; Computational biology; Genetics; Evolutionary biology; DNA; Gene; DNA damage","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005251702,0.0001732991,0.0002477867,0.0007172877,0.000512008,0.001140481,0.0003187715,0.001305529,0.001315581],"category_scores_gemma":[0.0006163424,0.0001393872,0.0001288425,0.000652916,0.002042023,0.001162441,0.0008766,0.001075017,0.0002787319],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002289443,"about_ca_system_score_gemma":0.0005273281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003085732,"about_ca_topic_score_gemma":0.004470595,"domain_scores_codex":[0.9997532,0.00005899752,0.00001404871,0.00003390638,0.00009416393,0.00004570206],"domain_scores_gemma":[0.9997022,0.00009288631,0.00006414943,0.00001578584,0.00005934663,0.00006569518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0007295852,0.00009201407,0.01823139,0.001845331,0.0001601354,0.00562045,0.004423452,0.006097235,0.1771654,0.3004743,0.05708328,0.4280775],"study_design_scores_gemma":[0.00003188442,0.0003366191,0.04541371,0.0006555627,0.00005264533,0.01808769,0.002378598,0.001453383,0.02454869,0.1292711,0.7776464,0.0001236936],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.08685323,0.8480112,0.004214969,0.03779308,0.001324069,0.00001616827,0.00007835448,0.00007848813,0.02163044],"genre_scores_gemma":[0.559622,0.4100785,0.001758185,0.008371517,0.002744798,0.00001938343,0.0001095865,0.00003717505,0.01725892],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003085732,"threshold_uncertainty_score":0.01661116,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02452625718010108,"score_gpt":0.3300238368005344,"score_spread":0.3054975796204333,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}