{"id":"W4315486401","doi":"10.3390/antiox12010160","title":"Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institutes of Health; American Heart Association","keywords":"Oxidative stress; Mitochondrion; Reactive oxygen species; Angiotensin II; Endothelial dysfunction; Mitochondrial ROS; Butyrate; Chemistry; Heme oxygenase; Inner mitochondrial membrane; Enos; Biology; Endocrinology; Biochemistry; Internal medicine; Cell biology; Heme; Nitric oxide; Nitric oxide synthase; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001816157,0.0003282806,0.0003558909,0.0002074586,0.0001498563,0.0002688409,0.0001950414,0.0003777033,0.001202061],"category_scores_gemma":[0.0001496225,0.00008756602,0.0003181126,0.0001383447,0.0001752155,0.0002498668,0.0002172534,0.0005599908,0.0001542816],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001478863,"about_ca_system_score_gemma":0.0002214517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005895062,"about_ca_topic_score_gemma":0.0009751126,"domain_scores_codex":[0.9998864,0.00002680952,0.00001065486,0.00001840213,0.00001855508,0.00003919556],"domain_scores_gemma":[0.9998951,0.000007860051,0.00003028229,0.000008730088,0.00002917579,0.00002880766],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001789945,0.0002201379,0.001271459,0.0004327775,0.00008747707,0.0004499751,0.00004530359,0.00008431905,0.9840164,0.00023178,0.0003227111,0.01104776],"study_design_scores_gemma":[0.0003040431,0.00335816,0.05282916,0.0002216926,0.0003038437,0.001403384,0.0004210054,0.002022818,0.9235867,0.0006564726,0.01486209,0.00003065182],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455607,0.04544544,0.00514928,0.001243605,0.0002769394,0.00004711704,0.0004480795,0.00007424012,0.00175459],"genre_scores_gemma":[0.9854938,0.01059526,0.001637299,0.0003089341,0.00005488101,0.0000416081,0.0002932459,0.00000687033,0.001568142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001202061,"threshold_uncertainty_score":0.004021227,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007996271131640876,"score_gpt":0.2292611435593099,"score_spread":0.221264872427669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}