{"id":"W4315486401","doi":"10.3390/antiox12010160","title":"Protective Role of Short-Chain Fatty Acids against Ang- II-Induced Mitochondrial Dysfunction in Brain Endothelial Cells: A Potential Role of Heme Oxygenase 2","year":2023,"lang":"en","type":"article","venue":"Antioxidants","topic":"Heme Oxygenase-1 and Carbon Monoxide","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Instituto de Salud Carlos III; National Institutes of Health; American Heart Association","keywords":"Oxidative stress; Mitochondrion; Reactive oxygen species; Angiotensin II; Endothelial dysfunction; Mitochondrial ROS; Butyrate; Chemistry; Heme oxygenase; Inner mitochondrial membrane; Enos; Biology; Endocrinology; Biochemistry; Internal medicine; Cell biology; Heme; Nitric oxide; Nitric oxide synthase; Medicine; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003103175,0.0002615087,0.0003504186,0.0001860999,0.00007405936,0.00001140648,0.0002351475,0.0003176565,0.00001618304],"category_scores_gemma":[0.0001318104,0.000272023,0.0002385242,0.0004040794,0.00007953894,0.00001423842,0.0001878348,0.0001685218,0.00001290396],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002523464,"about_ca_system_score_gemma":0.0001454372,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001848296,"about_ca_topic_score_gemma":0.0002319455,"domain_scores_codex":[0.9980332,0.0001662747,0.000520332,0.0005372012,0.0003036461,0.0004392995],"domain_scores_gemma":[0.999179,0.00001357591,0.0001679494,0.0004183332,0.0001196506,0.0001014936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005354523,0.0002085176,0.0006668979,0.00003079761,0.00007869293,0.0000131261,0.0002230985,0.0001472699,0.9929012,0.00001507494,0.0001695259,0.005010366],"study_design_scores_gemma":[0.001454775,0.0005324029,0.007640613,0.00004512093,0.00001692089,0.000004016954,0.0007902469,0.0006701538,0.9878078,0.0001460566,0.0006341132,0.0002577764],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981299,0.0001271943,0.0001560316,0.0000449532,0.0002936602,0.0006234334,0.0001928258,0.00003191318,0.0004000694],"genre_scores_gemma":[0.9989636,0.0000708183,0.0001358091,0.00005557148,0.000340534,0.00008108612,0.000115564,0.00004464951,0.0001923465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006973715,"threshold_uncertainty_score":0.9999732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007996271131640876,"score_gpt":0.2292611435593099,"score_spread":0.221264872427669,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}