{"id":"W4315488156","doi":"10.1016/j.ijrobp.2022.12.055","title":"PSMA-PET/CT-Guided Intensification of Radiation Therapy for Prostate Cancer (PSMAgRT): Findings of Detection Rate, Effect on Cancer Management, and Early Toxicity From a Phase 2 Randomized Controlled Trial","year":2023,"lang":"en","type":"article","venue":"International Journal of Radiation Oncology*Biology*Physics","topic":"Prostate Cancer Diagnosis and Treatment","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Integre de Sante et de Services Sociaux de Laval; La Cité Médicale; Hôpital Charles-Le Moyne; Centre Hospitalier de l’Université de Montréal","funders":"Lantheus Medical Imaging; Varian Medical Systems","keywords":"Medicine; Prostate cancer; Clinical endpoint; Salvage therapy; Randomized controlled trial; Radiation therapy; Cancer; Oncology; Internal medicine; Positron emission tomography; Prostate; Radiology; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004154363,0.001766952,0.003085657,0.0004609026,0.0003569159,0.00121097,0.001249616,0.001921822,0.00466468],"category_scores_gemma":[0.004017146,0.0008616269,0.003108485,0.0006439117,0.001717563,0.001272804,0.0004880216,0.003109146,0.0006311294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007879144,"about_ca_system_score_gemma":0.001037283,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001055219,"about_ca_topic_score_gemma":0.001582504,"domain_scores_codex":[0.998125,0.001248685,0.0000986805,0.0002719622,0.0001229078,0.0001327324],"domain_scores_gemma":[0.9970118,0.001585739,0.0006323901,0.0002824081,0.000105527,0.0003820843],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9879435,0.00244083,0.0005312806,0.0002910389,0.00154269,0.00001226636,0.00003177625,0.0002113296,0.001059495,0.00004272892,0.0001317297,0.005761323],"study_design_scores_gemma":[0.9451144,0.04988365,0.00233297,0.00002549426,0.001662063,0.00002140892,0.00001147342,0.0003744134,0.0003025358,0.00008117442,0.0001782314,0.00001212449],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9914486,0.004328708,0.0007454245,0.0003453477,0.0002528422,0.001398583,0.0004499583,0.00009005734,0.0009405232],"genre_scores_gemma":[0.9933985,0.001997154,0.001445883,0.0004526184,0.0002706106,0.00101361,0.0004543217,0.00002312329,0.0009441276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00466468,"threshold_uncertainty_score":0.02197069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02422531661670524,"score_gpt":0.3650715039158598,"score_spread":0.3408461872991546,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}