{"id":"W4315489431","doi":"10.1016/j.celrep.2022.111983","title":"Small CD4 mimetics sensitize HIV-1-infected macrophages to antibody-dependent cellular cytotoxicity","year":2023,"lang":"en","type":"article","venue":"Cell Reports","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; National Institute on Drug Abuse; National Heart, Lung, and Blood Institute; Mitacs; Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Center for AIDS Research, University of Alabama at Birmingham; National Institutes of Health; Canadian Institutes of Health Research; Canada Foundation for Innovation; Center for AIDS Research, University of Washington; University of Alabama; National Institute of Diabetes and Digestive and Kidney Diseases; ViiV Healthcare; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; University of Alabama at Birmingham","keywords":"Antibody-dependent cell-mediated cytotoxicity; Epitope; Cytotoxicity; Antibody; Chemistry; Virology; Downregulation and upregulation; In vitro; Cell biology; Biology; Molecular biology; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002236029,0.0003418234,0.0003011,0.0001584754,0.0001888374,0.0002701874,0.0002393331,0.0004436054,0.003350898],"category_scores_gemma":[0.0002437283,0.0001843676,0.000206782,0.0001091439,0.0003009642,0.0003078132,0.0002673293,0.0007013909,0.0005326145],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002053301,"about_ca_system_score_gemma":0.000141708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002000453,"about_ca_topic_score_gemma":0.000298117,"domain_scores_codex":[0.9998221,0.00005673814,0.00001086818,0.00002443472,0.0000467736,0.00003926352],"domain_scores_gemma":[0.9998906,0.00004987515,0.00001533036,0.00001505462,0.000009603538,0.00001949261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002900287,0.00008497815,0.000172846,0.0000898181,0.00001459886,0.00008774591,0.00002733843,0.0001232072,0.9950164,0.0002353742,0.0002224693,0.003635213],"study_design_scores_gemma":[0.0000827762,0.001069498,0.001246811,0.00000838454,0.00001356749,0.0003782416,0.00003116417,0.0004172467,0.9918947,0.0001853879,0.004666771,0.000005424592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9861916,0.00430708,0.003603912,0.0003490242,0.0001277188,0.0001161324,0.0001758432,0.00009434207,0.005034433],"genre_scores_gemma":[0.9900146,0.002020433,0.003116578,0.0002504042,0.00004865983,0.000108486,0.0002470446,0.00001734482,0.004176617],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003350898,"threshold_uncertainty_score":0.01120985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01797118430581306,"score_gpt":0.259993864331327,"score_spread":0.2420226800255139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}