{"id":"W4315489571","doi":"10.1523/jneurosci.1820-22.2022","title":"A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer’s Disease Mouse Models by Upregulating Neuronal Autophagy","year":2023,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health; Russian Science Foundation","keywords":"Autophagy; Ryanodine receptor; Cell biology; Biology; Alzheimer's disease; Neurodegeneration; Protein kinase A; Neuroscience; Kinase; Internal medicine; Intracellular; Medicine; Biochemistry; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004130231,0.0009653451,0.0007623927,0.0007067349,0.0003478295,0.00032521,0.0006485231,0.001077805,0.002085804],"category_scores_gemma":[0.0002373147,0.0004568491,0.0009974545,0.0002586956,0.0005186499,0.0004296311,0.0003931301,0.001260271,0.0006795446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003279611,"about_ca_system_score_gemma":0.000353802,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009983573,"about_ca_topic_score_gemma":0.001352887,"domain_scores_codex":[0.9995425,0.00004975444,0.0001163466,0.0001150112,0.00008893191,0.00008755858],"domain_scores_gemma":[0.9996117,0.00005113234,0.000144798,0.00004861066,0.00003267549,0.0001111902],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002054146,0.00007202793,0.00008302581,0.00003984595,0.00001602022,0.0001928306,0.00002689209,0.00005289716,0.9984615,0.0001321855,0.00006133592,0.0006559234],"study_design_scores_gemma":[0.0002154384,0.001253161,0.005843114,0.00004065032,0.0001053533,0.001280698,0.00008392033,0.001917848,0.9848312,0.000205889,0.004180579,0.00004221647],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990056,0.001018892,0.005631794,0.0002792734,0.0001670003,0.000102433,0.00121426,0.0003602793,0.001169971],"genre_scores_gemma":[0.9859126,0.001363126,0.00499397,0.0001882691,0.00005268147,0.0002480643,0.001228227,0.0001812904,0.005831856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002085804,"threshold_uncertainty_score":0.006977737,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07098339665010918,"score_gpt":0.3483720569982043,"score_spread":0.2773886603480951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}