{"id":"W4315490452","doi":"10.1039/d2ob02099h","title":"Effective carrier-free gene-silencing activity of sphingosine-modified siRNAs","year":2023,"lang":"en","type":"article","venue":"Organic & Biomolecular Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Tech University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Small interfering RNA; Gene knockdown; Gene silencing; RNA interference; Sphingosine; Chemistry; Transfection; Oligonucleotide; Cell biology; RNA; Biochemistry; Gene; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002607169,0.0004927196,0.0002366847,0.0002059634,0.0001776526,0.0002524612,0.000180739,0.0004042525,0.001872545],"category_scores_gemma":[0.0003137779,0.000138805,0.0001597182,0.0001342052,0.0002465173,0.0002697185,0.0001665918,0.000538122,0.0006051882],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768048,"about_ca_system_score_gemma":0.0003437941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006238612,"about_ca_topic_score_gemma":0.00104841,"domain_scores_codex":[0.9998441,0.00002765465,0.00001635123,0.00003292598,0.00006121863,0.00001768573],"domain_scores_gemma":[0.9998105,0.00008667287,0.00002903289,0.00001442819,0.00003234112,0.00002706077],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001227375,0.000004151604,0.00001325606,0.00002134194,0.00000208205,0.00001355156,0.000009010223,0.00002148432,0.9992552,0.00007157964,0.00002448906,0.0005515425],"study_design_scores_gemma":[0.000003733364,0.00005140894,0.0002570126,0.000002183681,0.000005309855,0.00003475061,0.000004264237,0.0001676267,0.9983159,0.00002373031,0.001131385,0.000002681129],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9534197,0.006189047,0.02801587,0.0002800452,0.0001250815,0.0001374716,0.0007708964,0.000548729,0.01051311],"genre_scores_gemma":[0.9849951,0.001526503,0.007130487,0.00008850226,0.00001905583,0.0001159708,0.0006484932,0.00005496467,0.005420951],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001872545,"threshold_uncertainty_score":0.006264269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007341209097517055,"score_gpt":0.2375398435678787,"score_spread":0.2301986344703616,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}