{"id":"W4315497925","doi":"10.3389/fimmu.2022.1078880","title":"Dynamic changes in human THP-1-derived M1-to-M2 macrophage polarization during Thelazia callipaeda MIF induction","year":2023,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Macrophage Migration Inhibitory Factor","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Petroleum Technology Research Centre; Guizhou Science and Technology Department; National Natural Science Foundation of China","keywords":"Macrophage polarization; Macrophage migration inhibitory factor; PI3K/AKT/mTOR pathway; Western blot; Immune system; Flow cytometry; Cell biology; Biology; Protein kinase B; Inflammation; Signal transduction; Macrophage; Chemistry; Molecular biology; Immunology; Cytokine; In vitro; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001151085,0.0002484548,0.0002121008,0.0002309603,0.0002455207,0.0002098515,0.00008429124,0.0002323771,0.000812633],"category_scores_gemma":[0.0000780668,0.00009418577,0.0001892619,0.0001742964,0.0001523638,0.0001321435,0.0001344515,0.000492895,0.0002817191],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001542568,"about_ca_system_score_gemma":0.0001275783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005269191,"about_ca_topic_score_gemma":0.0005922661,"domain_scores_codex":[0.9998813,0.00001354426,0.000009060042,0.00002370482,0.000022183,0.000050193],"domain_scores_gemma":[0.9999398,0.00001053936,0.00001259219,0.000004137766,0.00001723645,0.00001560103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001114276,0.00001325974,0.0003204221,0.00002457185,0.000001496901,0.00003988819,0.00003359332,0.00001019638,0.9989654,0.00001944855,0.00001953663,0.0004406567],"study_design_scores_gemma":[0.00002343504,0.0003772778,0.03330489,0.00001215603,0.00002431986,0.0002609064,0.000251181,0.0005232484,0.9626693,0.00006909738,0.002470002,0.00001414637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946789,0.00110391,0.002006648,0.00008969443,0.00003736165,0.00004622492,0.0007820039,0.0000361181,0.001219223],"genre_scores_gemma":[0.9946371,0.0006859794,0.002076118,0.0001310054,0.00002290142,0.0001068416,0.0007855041,0.000009224324,0.0015454],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000812633,"threshold_uncertainty_score":0.002718508,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008316574099571924,"score_gpt":0.2347027860909266,"score_spread":0.2263862119913547,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}