{"id":"W4315567536","doi":"10.3390/biomedicines11010177","title":"Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Science and Technology, Taiwan; Chang Gung Medical Foundation","keywords":"Toxic epidermal necrolysis; Acute generalized exanthematous pustulosis; Immunology; Medicine; Drug allergy; Delayed hypersensitivity; Drug; Drug eruption; Immune system; Allergy; Pharmacology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004683874,0.0008461157,0.001264171,0.00129469,0.0002456473,0.0009807168,0.0006191898,0.0007880969,0.002593903],"category_scores_gemma":[0.0004942055,0.0002019786,0.0006241404,0.001151088,0.0004610351,0.001303624,0.0005386164,0.001295108,0.0006854254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005925493,"about_ca_system_score_gemma":0.0005876172,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006497666,"about_ca_topic_score_gemma":0.0006262151,"domain_scores_codex":[0.9996657,0.0000766267,0.00005419167,0.00005653526,0.0001011418,0.00004570879],"domain_scores_gemma":[0.999697,0.000126268,0.00007249245,0.000008346102,0.00007360519,0.00002235986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0004389668,0.0002803952,0.004174422,0.03376662,0.0003255593,0.004267226,0.0004564712,0.0008030257,0.02482608,0.009365791,0.04283475,0.8784606],"study_design_scores_gemma":[0.00005415182,0.0006891302,0.01084593,0.006154517,0.0005138845,0.03228672,0.0005305151,0.0005926208,0.007091806,0.008342271,0.9328007,0.00009774472],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001106573,0.9964724,0.0005913674,0.0003286263,0.0002454584,0.00001232343,0.00003592233,0.00001292032,0.001194435],"genre_scores_gemma":[0.009101922,0.9873875,0.0007696607,0.000445465,0.0007066927,0.00002143093,0.0001134589,0.000003051038,0.001450901],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002593903,"threshold_uncertainty_score":0.008677483,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06008864209769794,"score_gpt":0.3443178776520059,"score_spread":0.284229235554308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}