{"id":"W4315567536","doi":"10.3390/biomedicines11010177","title":"Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators","year":2023,"lang":"en","type":"review","venue":"Biomedicines","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Science and Technology, Taiwan; Chang Gung Medical Foundation","keywords":"Toxic epidermal necrolysis; Acute generalized exanthematous pustulosis; Immunology; Medicine; Drug allergy; Delayed hypersensitivity; Drug; Drug eruption; Immune system; Allergy; Pharmacology; Dermatology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006423566,0.0007111191,0.002333802,0.001227902,0.000166613,0.00002834992,0.0001272862,0.0005053823,0.0000218888],"category_scores_gemma":[0.001034574,0.0005749452,0.0005566618,0.001649778,0.0004939482,0.00009530721,0.0001442373,0.0007311787,0.0006609173],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003302901,"about_ca_system_score_gemma":0.0005966951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006248167,"about_ca_topic_score_gemma":0.00006941725,"domain_scores_codex":[0.9964259,0.0002717187,0.00123303,0.0009656443,0.0005898013,0.0005138714],"domain_scores_gemma":[0.9971172,0.0006695401,0.0005150964,0.000906768,0.0003064075,0.0004849929],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000005778291,0.000142847,0.00000538977,0.0129877,0.0008489058,0.0006162205,0.00008315364,4.074993e-8,0.0005397253,0.000008287896,0.0003639493,0.984398],"study_design_scores_gemma":[0.0009296667,0.00007356684,0.0004290328,0.01933884,0.006997488,0.002430985,0.0006372125,0.000007432159,0.00003400631,0.0001856523,0.9682742,0.0006618885],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001490006,0.9917166,0.00001773568,0.0004949392,0.001653865,0.002036145,0.0002141068,0.0005427295,0.001833854],"genre_scores_gemma":[0.0005091623,0.9953958,0.000417366,0.00008034505,0.001107001,0.0001923815,0.001173755,0.0001995619,0.0009246332],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9837361,"threshold_uncertainty_score":0.9996702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06008864209769794,"score_gpt":0.3443178776520059,"score_spread":0.284229235554308,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}