{"id":"W4315619235","doi":"10.1096/fj.202201359r","title":"Distinct effects of <scp>SDC3</scp> and <scp>FGFRL1</scp> on selective neurodegeneration in <scp>AD</scp> and <scp>PD</scp>","year":2023,"lang":"en","type":"article","venue":"The FASEB Journal","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"China Scholarship Council","keywords":"Neurodegeneration; Dopaminergic; Cholinergic; Cell biology; Chemistry; Basal forebrain; Cholinergic neuron; Neuroscience; Biology; Dopamine; Internal medicine; Medicine; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001128365,0.0007684449,0.001032904,0.0007544418,0.0007343859,0.0002201821,0.0003208124,0.0003038545,0.000004429322],"category_scores_gemma":[0.004387503,0.0005697855,0.000287376,0.001131774,0.0002603458,0.0003295859,0.0002086249,0.001124935,0.00008938552],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002523844,"about_ca_system_score_gemma":0.0003181354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006470059,"about_ca_topic_score_gemma":0.00006739025,"domain_scores_codex":[0.995379,0.0007011019,0.0008050055,0.0008662027,0.001080548,0.001168122],"domain_scores_gemma":[0.9937814,0.003897013,0.0006470631,0.0005745375,0.0002604476,0.0008395261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002376622,0.004447171,0.2723572,0.00176048,0.003470586,0.008829666,0.02038914,0.0007522929,0.6135914,0.001869088,0.05406692,0.01822846],"study_design_scores_gemma":[0.009408997,0.002832843,0.7078661,0.0008068868,0.001140525,0.00103426,0.00212111,0.003235228,0.2651105,0.002512004,0.003848652,0.00008288422],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932075,0.002518582,0.000225401,0.0001472326,0.000692753,0.001220649,0.0001062676,0.0001454788,0.001736111],"genre_scores_gemma":[0.9942268,0.001724543,0.000171899,0.0003970919,0.0005079224,0.0001002948,0.0001064407,0.0001356835,0.002629343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.435509,"threshold_uncertainty_score":0.9996753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01374170638262521,"score_gpt":0.2497476907635712,"score_spread":0.236005984380946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}