{"id":"W4315619492","doi":"10.1093/nar/gkac1248","title":"Metabolically-targeted dCas9 expression in bacteria","year":2023,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Bacterial Genetics and Biotechnology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph; Western University","funders":"Canadian Institutes of Health Research","keywords":"Biology; Gammaproteobacteria; Escherichia coli; Operon; Bacteria; Transcription (linguistics); Transcription factor; Regulation of gene expression; Alphaproteobacteria; Gene expression; Actinobacteria; Genetics; Gene; Microbiology; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002833933,0.0003998459,0.0003628257,0.0001900763,0.0001838985,0.0004687756,0.0003035129,0.0004369296,0.000646703],"category_scores_gemma":[0.0002442584,0.0002109428,0.0003124439,0.0002286623,0.000373361,0.0001872712,0.0004821685,0.0007040644,0.0006628023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006075931,"about_ca_system_score_gemma":0.0003003316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007286779,"about_ca_topic_score_gemma":0.0009851712,"domain_scores_codex":[0.9996386,0.00005989699,0.00003582252,0.0001068626,0.00009985807,0.00005898345],"domain_scores_gemma":[0.9998263,0.0000381345,0.00004617242,0.00003839367,0.00002145831,0.00002966635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001927922,0.000007242219,0.0000401018,0.00001720991,0.00000149286,0.000008070539,0.000005667242,0.00005097897,0.9991924,0.00009187056,0.00001677966,0.0005488177],"study_design_scores_gemma":[0.000002424186,0.00003014953,0.0002300788,0.000002611658,0.000003171177,0.00003186722,0.000009011789,0.0003928921,0.9977298,0.00002690531,0.001538646,0.000002414215],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9393335,0.001517747,0.05298052,0.0005286227,0.0001437356,0.0001650331,0.001650927,0.0005170351,0.003162764],"genre_scores_gemma":[0.9536199,0.00110013,0.03732693,0.000177737,0.00001634026,0.0001118379,0.00195579,0.0002366037,0.005454708],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007286779,"threshold_uncertainty_score":0.004408419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03315142551571514,"score_gpt":0.3304323861602652,"score_spread":0.2972809606445501,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}