{"id":"W4315619806","doi":"10.1128/mbio.03370-22","title":"A Germline-Targeting Chimpanzee SIV Envelope Glycoprotein Elicits a New Class of V2-Apex Directed Cross-Neutralizing Antibodies","year":2023,"lang":"en","type":"article","venue":"mBio","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Centre Hospitalier de l’Université de Montréal","funders":"Canadian Institutes of Health Research; National Institutes of Health; Vaccine Research Center; Center for AIDS Research, University of Washington; University of Pennsylvania; National Institute of Allergy and Infectious Diseases; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Germline; Biology; Apex (geometry); Glycoprotein; Antibody; Virology; Cell biology; Primate; Immunology; Genetics; Gene; Neuroscience; Anatomy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001391398,0.0002879526,0.000141004,0.0001303305,0.00009923985,0.0002137944,0.0001160689,0.0002035418,0.001037154],"category_scores_gemma":[0.0001343538,0.00009942787,0.0001405553,0.00004955861,0.0001581727,0.0001024387,0.0001485216,0.0005008453,0.0001034774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001284023,"about_ca_system_score_gemma":0.00006596955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002448243,"about_ca_topic_score_gemma":0.0005494925,"domain_scores_codex":[0.9999235,0.00001377071,0.000004390341,0.00002225902,0.00001651526,0.00001955211],"domain_scores_gemma":[0.9999297,0.00002009337,0.00001227581,0.00001135506,0.000008798864,0.00001778592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004771129,0.00001538664,0.001010117,0.00001663054,0.000006435338,0.00005625958,0.00001704254,0.00005106187,0.9968708,0.00006052707,0.00001979622,0.001828353],"study_design_scores_gemma":[0.00007474585,0.002787244,0.04431656,0.0000239201,0.00007359363,0.004654224,0.0001726689,0.002196192,0.9385439,0.0003013916,0.00684417,0.00001131998],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976199,0.0002971678,0.001282876,0.00002182636,0.000005784458,0.00001517412,0.00004124108,0.00002080478,0.0006950654],"genre_scores_gemma":[0.9972392,0.0001805684,0.001761667,0.00005159452,0.000006657208,0.00001013347,0.0001464431,0.000007443358,0.0005961821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001037154,"threshold_uncertainty_score":0.003469586,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02582452221830018,"score_gpt":0.3099098500087099,"score_spread":0.2840853277904097,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}