{"id":"W4315630495","doi":"10.1016/j.modpat.2022.100057","title":"In Reply: Programmed Death-Ligand 1 (PD-L1) Immunohistochemistry Calibration","year":2023,"lang":"en","type":"letter","venue":"Modern Pathology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Health Authority","funders":"National Cancer Institute; National Institutes of Health","keywords":"Immunohistochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.0003064887,0.000377375,0.0007019973,0.0002535215,0.00005523545,0.00002682193,0.0001919383,0.001365271,0.00009219132],"category_scores_gemma":[0.00007369764,0.0003605413,0.0002365175,0.0002363296,0.0001731959,0.00005632245,0.00006640364,0.001558795,0.00004346393],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003556022,"about_ca_system_score_gemma":0.0002820026,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002396158,"about_ca_topic_score_gemma":0.00001715022,"domain_scores_codex":[0.9976603,0.0001040582,0.0005983451,0.0007758733,0.0002840399,0.0005773269],"domain_scores_gemma":[0.9987743,0.00007549506,0.0002186551,0.0008296065,0.00005661136,0.00004535814],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001298017,0.00009765284,0.0008293343,0.000586162,0.0001597751,0.01526778,0.0006868838,0.000001677517,0.1382583,0.000001900248,0.8371456,0.005666858],"study_design_scores_gemma":[0.006447524,0.0007028382,0.003169968,0.0006648587,0.0002831386,0.003338619,0.00004494849,0.0007277586,0.01620286,0.001599898,0.9657528,0.001064796],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.1434872,0.003939131,0.0005665271,0.8464201,0.001828005,0.001663573,0.0001106877,0.0004638294,0.001520914],"genre_scores_gemma":[0.02337406,0.0005496877,0.0004542993,0.9249737,0.003377375,0.0008923119,0.003451478,0.0002912095,0.04263588],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.1286072,"threshold_uncertainty_score":0.9999312,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819661316858195,"score_gpt":0.3005435035127841,"score_spread":0.2723468903442022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}