{"id":"W4315630495","doi":"10.1016/j.modpat.2022.100057","title":"In Reply: Programmed Death-Ligand 1 (PD-L1) Immunohistochemistry Calibration","year":2023,"lang":"en","type":"letter","venue":"Modern Pathology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; Saskatchewan Health Authority","funders":"National Cancer Institute; National Institutes of Health","keywords":"Immunohistochemistry; Pathology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0038848,0.0009132818,0.001256146,0.000964085,0.003126361,0.003950683,0.001508164,0.03906055,0.004030079],"category_scores_gemma":[0.0252339,0.0009187117,0.001010048,0.0007997878,0.003463112,0.002914487,0.001697612,0.03918987,0.004446089],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003885159,"about_ca_system_score_gemma":0.002434227,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001925674,"about_ca_topic_score_gemma":0.003559361,"domain_scores_codex":[0.9966559,0.001036667,0.0004385475,0.0003776106,0.001036952,0.0004542371],"domain_scores_gemma":[0.990507,0.004978836,0.0008055064,0.0004308034,0.002146312,0.001131483],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000586241,0.00002522175,0.000948797,0.00007838212,0.00002254021,0.00233928,0.0000856948,0.00007021948,0.0004154767,0.001568888,0.9870395,0.007347362],"study_design_scores_gemma":[0.0001834342,0.0001080553,0.001990426,0.0003150007,0.00009788766,0.009437522,0.0005496677,0.0007692223,0.001020752,0.01099007,0.9744394,0.00009853447],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0003390245,0.001433249,0.0002082624,0.9617727,0.03484322,0.00001539056,0.00003629984,0.00003073227,0.001321158],"genre_scores_gemma":[0.004326564,0.001290583,0.000441236,0.9340421,0.05599502,0.00005531862,0.00003825988,0.00002261796,0.003788227],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.03906055,"threshold_uncertainty_score":0.028189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02819661316858195,"score_gpt":0.3005435035127841,"score_spread":0.2723468903442022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}