{"id":"W4315642056","doi":"10.34133/research.0056","title":"Restoration of Motor Function through Delayed Intraspinal Delivery of Human IL-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury","year":2023,"lang":"en","type":"article","venue":"Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Nemzeti Kutatási Fejlesztési és Innovációs Hivatal","keywords":"Neuroprotection; Spinal cord; Spinal cord injury; Medicine; Neurotrophic factors; Nucleoside; Pharmacology; Messenger RNA; In vivo; Microglia; Anesthesia; Immunology; Inflammation; Biology; Internal medicine; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000661055,0.0001169854,0.0001638511,0.0002126031,0.0001142027,0.00002274485,0.0002309358,0.0001758602,0.00008702681],"category_scores_gemma":[0.00009025863,0.0001172681,0.00009995976,0.000365968,0.0001885003,0.00002096325,0.0001939668,0.0001858476,0.00005689649],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003160547,"about_ca_system_score_gemma":0.0001227961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002855619,"about_ca_topic_score_gemma":0.0000606126,"domain_scores_codex":[0.9984197,0.0001646917,0.0003468613,0.0003256642,0.0004244916,0.0003185655],"domain_scores_gemma":[0.9988863,0.00001918331,0.00009563009,0.0003627268,0.0005816328,0.0000545045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008259122,0.00005567612,0.0004338308,0.00006995746,0.00005647356,0.000005710162,0.00004444433,0.00001184485,0.9830351,0.0001454158,0.004413633,0.003468823],"study_design_scores_gemma":[0.0004294527,0.01690457,0.01912068,0.0001311797,0.00002244458,0.000002900684,0.0004097559,0.000200781,0.9600474,0.0005773313,0.00195966,0.0001938669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982949,0.0002406482,0.0002225945,0.00005063682,0.0001137609,0.0002049119,0.00004684153,0.00001324453,0.0008124072],"genre_scores_gemma":[0.9983044,0.0003434352,0.00006852293,0.0000215946,0.0002206434,0.00004441883,0.0001218918,0.00001858638,0.0008565188],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02298769,"threshold_uncertainty_score":0.4782055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08800470662193836,"score_gpt":0.3974732690615994,"score_spread":0.309468562439661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}