{"id":"W4315645017","doi":"10.1038/s41396-023-01358-4","title":"CRISPR-Cas provides limited phage immunity to a prevalent gut bacterium in gnotobiotic mice","year":2023,"lang":"en","type":"article","venue":"The ISME Journal","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Danish Agency for Science and Higher Education; Canadian Institutes of Health Research; Danmarks Frie Forskningsfond; Ministeriet for Forskning Innovation og Videregående Uddannelser; Canada Research Chairs","keywords":"Biology; Microbiology; Bacteria; Immunity; CRISPR; Virology; Phage therapy; Bacteriophage; Immunology; Immune system; Escherichia coli; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003823262,0.0009713711,0.0006259454,0.001150359,0.0002450737,0.0006579436,0.0005350999,0.001091152,0.002890758],"category_scores_gemma":[0.000291452,0.0005138169,0.0006921864,0.0002376067,0.0009085988,0.0004449185,0.0006471722,0.002179501,0.0007253074],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004412275,"about_ca_system_score_gemma":0.0003568582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004647767,"about_ca_topic_score_gemma":0.000712297,"domain_scores_codex":[0.999267,0.00009109888,0.00008242666,0.0002604064,0.0001540047,0.0001450031],"domain_scores_gemma":[0.9991704,0.00009656733,0.0002855659,0.0001147196,0.00003814418,0.0002946347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003410513,0.00008894501,0.0002786806,0.00004583066,0.00001034027,0.00008098898,0.00002474079,0.00006985703,0.9980255,0.0001366002,0.00003895158,0.0008583888],"study_design_scores_gemma":[0.0001130965,0.001714567,0.006036583,0.00003496741,0.00004286099,0.0007437554,0.00007328942,0.001965254,0.9865144,0.0001966186,0.002543554,0.00002119781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9897346,0.0006873547,0.005113033,0.0002848249,0.00006963645,0.00009714423,0.0009501491,0.0004904906,0.002572835],"genre_scores_gemma":[0.9873769,0.0005074557,0.004628761,0.0002273965,0.00002659988,0.0001713268,0.0007832227,0.0001276048,0.006150796],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002890758,"threshold_uncertainty_score":0.009670556,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01427482961670261,"score_gpt":0.3128177267925684,"score_spread":0.2985428971758657,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}