{"id":"W4315647508","doi":"10.3390/toxins15010060","title":"Clinical Immunogenicity of DaxibotulinumtoxinA for Injection in Glabellar Lines: Pooled Data from the SAKURA Phase 3 Trials","year":2023,"lang":"en","type":"article","venue":"Toxins","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health; University of British Columbia","funders":"Revance","keywords":"Immunogenicity; Clinical trial; Medicine; Virology; Internal medicine; Immunology; Antibody","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007158466,0.0007883418,0.001760219,0.0003127491,0.0002219768,0.0007615417,0.0003896449,0.0007270215,0.001730144],"category_scores_gemma":[0.004274548,0.000262905,0.002333491,0.0005106027,0.0004238904,0.0005541259,0.0002796481,0.0009606283,0.0004463158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005355799,"about_ca_system_score_gemma":0.0005352597,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003653061,"about_ca_topic_score_gemma":0.0006276255,"domain_scores_codex":[0.9973817,0.001632152,0.0002806511,0.0002108756,0.0003333806,0.0001611885],"domain_scores_gemma":[0.9953566,0.001727058,0.001789866,0.0003115739,0.0005072333,0.000307568],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.6452567,0.004617331,0.03854287,0.007734341,0.02081114,0.0002998736,0.0003632081,0.002136563,0.06341984,0.0001474974,0.005499682,0.2111709],"study_design_scores_gemma":[0.1903139,0.5258011,0.2275957,0.0007353852,0.02324726,0.001139827,0.000204188,0.001635819,0.01705796,0.0003086575,0.01187361,0.00008670893],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9528211,0.0388768,0.0022166,0.0004201448,0.0001418446,0.001307081,0.00147969,0.000112284,0.002624397],"genre_scores_gemma":[0.9878584,0.007493884,0.0008205725,0.0005134145,0.0002200527,0.0007455881,0.001691649,0.00003463703,0.0006218368],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007158466,"threshold_uncertainty_score":0.03785807,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2871269441614118,"score_gpt":0.4714639204015129,"score_spread":0.1843369762401011,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}