{"id":"W4315698938","doi":"10.3390/ecmc2022-12906","title":"Prodrugs Activated by Vascular Ectopeptidases: Proof of Concept","year":2022,"lang":"en","type":"article","venue":"ECMC 2022","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Bradykinin; Receptor; Vascular smooth muscle; Histamine; Prodrug; Chemistry; Pharmacology; Angiotensin II; Endocrinology; Internal medicine; Biochemistry; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006633979,0.0006890488,0.0003015119,0.0001795588,0.0001377468,0.0005632277,0.000550359,0.0008904957,0.002339095],"category_scores_gemma":[0.0003578033,0.000223833,0.000345414,0.0001315423,0.0003087246,0.0007807821,0.0003676172,0.0014109,0.0008592919],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003492088,"about_ca_system_score_gemma":0.0004141049,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000373029,"about_ca_topic_score_gemma":0.0002503073,"domain_scores_codex":[0.9997717,0.00003584082,0.00001179225,0.00003637886,0.00008777012,0.0000565693],"domain_scores_gemma":[0.9998965,0.00001299298,0.00002241559,0.000008039247,0.00002603331,0.00003403037],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000520087,0.0007196552,0.0001730509,0.001264642,0.00005331834,0.0009484291,0.0001512506,0.00117302,0.9198714,0.009657297,0.006769148,0.05869875],"study_design_scores_gemma":[0.0004269517,0.006210689,0.0009531919,0.0001194614,0.00006111811,0.001531051,0.00005320282,0.002712587,0.8753981,0.001258667,0.1112217,0.0000533133],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.4932207,0.07981096,0.3446018,0.008599469,0.003983894,0.004988777,0.003401028,0.001736361,0.05965706],"genre_scores_gemma":[0.8422071,0.03732445,0.09784424,0.001736445,0.000408258,0.001498216,0.001428539,0.00009121065,0.01746156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002339095,"threshold_uncertainty_score":0.007825077,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009934045562580802,"score_gpt":0.2389218169424937,"score_spread":0.2289877713799129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}