{"id":"W4315705510","doi":"10.1097/01.hjh.0000913580.70984.fb","title":"S-39-3: ENDOTHELIAL INFLAMMATION AND DYSFUNCTION INDUCED BY SARS-COV-2 SPIKE PROTEIN 1 INVOLVE ADAM17 AND INTERFERON ACTIVATION PATHWAYS","year":2023,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Atherosclerosis and Cardiovascular Diseases","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"","keywords":"ISG15; Interferon-stimulated gene; Inflammation; Interferon; Medicine; TMPRSS2; Interferon gamma; Endocrinology; Receptor; Immunology; Cytokine; Molecular biology; Internal medicine; Gene; Biology; Innate immune system; Ubiquitin; Biochemistry; Coronavirus disease 2019 (COVID-19)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306422,0.0004211269,0.0002562717,0.0001845963,0.0001774405,0.0002541782,0.0001240892,0.0002834617,0.002859459],"category_scores_gemma":[0.00007603357,0.0001106915,0.0004478641,0.0001232392,0.0002056171,0.0001536005,0.0001468812,0.0005129541,0.0005549812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002985809,"about_ca_system_score_gemma":0.0001836714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003236916,"about_ca_topic_score_gemma":0.0004045035,"domain_scores_codex":[0.9998481,0.00002012725,0.00001445007,0.00003187968,0.00004342804,0.00004204291],"domain_scores_gemma":[0.9999266,0.000005563176,0.00002838966,0.000007422474,0.000008636875,0.00002343123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002369517,0.00003432206,0.0003670781,0.00003668546,0.000005563001,0.00008314772,0.0000105068,0.00002461942,0.9983611,0.00005516228,0.00005589242,0.0007289919],"study_design_scores_gemma":[0.00004973797,0.0006049732,0.02138189,0.00002177129,0.00002654205,0.0009447169,0.00005637867,0.0006990142,0.9723561,0.0001133273,0.00374059,0.000004913401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944406,0.001492781,0.001473267,0.0002289936,0.00004966333,0.00003638717,0.0007386474,0.00006196553,0.001477547],"genre_scores_gemma":[0.9928167,0.000860448,0.001228268,0.0001342407,0.00002526406,0.00004857178,0.001579978,0.00001458911,0.003292014],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002859459,"threshold_uncertainty_score":0.00956589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04375193066624029,"score_gpt":0.2228137592249048,"score_spread":0.1790618285586645,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}