{"id":"W4315709064","doi":"10.1073/pnas.2207291120","title":"Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity","year":2023,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Multiple Sclerosis Research Studies","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital; McGill University; University of British Columbia","funders":"National Institute of Neurological Disorders and Stroke; National Institute of Allergy and Infectious Diseases; National Cancer Institute; Kanae Foundation for the Promotion of Medical Science; Japan Society for the Promotion of Science; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Uehara Memorial Foundation; Nakatomi Foundation","keywords":"CD8; CD20; Immunology; CD38; CD19; Immune system; Cytotoxic T cell; Biology; Medicine; Flow cytometry; Cancer research; Antigen; CD34; Cell biology; Stem cell; Genetics; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406692,0.0002124206,0.000415112,0.0001693134,0.00009705912,0.0003630567,0.0001130215,0.000288503,0.0007971867],"category_scores_gemma":[0.0004912335,0.00009773357,0.0001674313,0.0001080499,0.0001670685,0.0001914286,0.0001212799,0.0004467659,0.0002044689],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001574113,"about_ca_system_score_gemma":0.0001713085,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001439545,"about_ca_topic_score_gemma":0.0003372721,"domain_scores_codex":[0.9997029,0.00007998971,0.00002567209,0.00005526329,0.00004650105,0.00008969766],"domain_scores_gemma":[0.999707,0.0001030847,0.00005605446,0.00002868894,0.00002285565,0.00008232058],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007529331,0.0008212996,0.03253448,0.0001264874,0.00005385139,0.0001927749,0.0001308442,0.0004432703,0.9118315,0.0000767601,0.0001558986,0.04610345],"study_design_scores_gemma":[0.00038321,0.03709098,0.4618079,0.0000388071,0.0002988671,0.00124443,0.0001817729,0.003263022,0.4912907,0.0002168428,0.004161024,0.00002241521],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986487,0.0006698263,0.0001350335,0.00001707581,0.000007842172,0.00001509021,0.00005540095,0.000008981538,0.0004420451],"genre_scores_gemma":[0.999263,0.0001599945,0.0001294645,0.00003276011,0.00001370965,0.00001791154,0.0001004252,0.000002829181,0.0002799857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007971867,"threshold_uncertainty_score":0.002666831,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06143880688018702,"score_gpt":0.3556231037104051,"score_spread":0.2941842968302181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}