{"id":"W4315753908","doi":"10.1007/s00125-022-05856-6","title":"Loss of RREB1 in pancreatic beta cells reduces cellular insulin content and affects endocrine cell gene expression","year":2023,"lang":"en","type":"article","venue":"Diabetologia","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Stanford Maternal and Child Health Research Institute; National Institute of Diabetes and Digestive and Kidney Diseases; Medical Research Council; University of Oxford; National Institutes of Health; Uppsala Universitet; Vetenskapsrådet; National Institute for Health and Care Research; Broad Institute; Wellcome Trust","keywords":"Biology; Zebrafish; Gene knockdown; Transcription factor; Beta cell; Cell biology; Cell growth; Transcriptome; Islet; Insulin; Gene expression; Internal medicine; Endocrinology; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002699268,0.0005816042,0.0004260436,0.0003206414,0.0001744977,0.0005101156,0.000380628,0.0003905357,0.003206408],"category_scores_gemma":[0.0001985218,0.0002361984,0.0004267152,0.0001674965,0.0003488684,0.0002780911,0.0004150953,0.001028882,0.000911023],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002472171,"about_ca_system_score_gemma":0.0001818455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003231837,"about_ca_topic_score_gemma":0.0003291916,"domain_scores_codex":[0.9997371,0.00002162631,0.0000263236,0.0001017753,0.00007006899,0.00004306635],"domain_scores_gemma":[0.9996824,0.00005030737,0.0001327697,0.00003862389,0.00002641402,0.00006948497],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004786615,0.0000114077,0.0002787372,0.00003188603,0.000006016693,0.00004135218,0.000005318176,0.00004111679,0.9988148,0.00003577191,0.00002709037,0.0006586505],"study_design_scores_gemma":[0.00002176609,0.0001515473,0.008363299,0.00001316361,0.00003883939,0.0004384896,0.00003579789,0.0005690715,0.9879048,0.00006847173,0.0023871,0.000007614924],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825516,0.002666595,0.01014419,0.00033545,0.00008890794,0.00003983196,0.001599364,0.0004560038,0.002118176],"genre_scores_gemma":[0.98702,0.001479133,0.004113621,0.0002155095,0.00002510587,0.00007631144,0.001337954,0.0001494624,0.005582918],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003206408,"threshold_uncertainty_score":0.01072651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02667341670597071,"score_gpt":0.2464017408125653,"score_spread":0.2197283241065946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}