{"id":"W4315754001","doi":"10.1097/hep.0000000000000045","title":"Checkpoint inhibitor hepatotoxicity: pathogenesis and management","year":2023,"lang":"en","type":"review","venue":"Hepatology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Toronto Liver Centre; University Health Network","funders":"","keywords":"Pathogenesis; Medicine; Intensive care medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002790728,0.0004096182,0.001926867,0.0003814769,0.00006748219,0.00001591714,0.0001073605,0.0004699564,0.0001043389],"category_scores_gemma":[0.00001822492,0.0003215768,0.0004972973,0.0004263961,0.0001993561,0.00001810456,0.0001703917,0.0002369557,0.0002381574],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001694143,"about_ca_system_score_gemma":0.0001556707,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000455443,"about_ca_topic_score_gemma":0.00003650488,"domain_scores_codex":[0.9980654,0.0001223054,0.0006755904,0.0005872426,0.0001713816,0.0003781297],"domain_scores_gemma":[0.9990824,0.00008063149,0.0002176688,0.0004688529,0.00002542846,0.0001249848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00008955885,0.00005111978,0.0002454215,0.04646127,0.0009844896,0.0009732011,0.00001829453,7.274595e-10,0.000007114895,0.0001350493,0.002263287,0.9487712],"study_design_scores_gemma":[0.00064254,0.0001314171,0.00006549348,0.007924207,0.001473465,0.001037509,0.00001319384,0.000004982883,0.000008031743,0.00002400653,0.9883902,0.0002849275],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003398971,0.9965941,0.000009928828,0.0001651365,0.0005494473,0.001383252,0.00004654694,0.0001750904,0.000736636],"genre_scores_gemma":[0.00001403924,0.9966527,0.0002142993,0.0003443368,0.0001914497,0.0004316902,0.0001100303,0.0001000332,0.001941414],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986127,"threshold_uncertainty_score":0.9999236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07329655356148833,"score_gpt":0.3506948007920936,"score_spread":0.2773982472306052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}