{"id":"W4315767675","doi":"10.1101/2023.01.11.523042","title":"Measuring prion propagation in single bacteria elucidates mechanism of loss","year":2023,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Concordia University","funders":"","keywords":"Biology; Prion protein; Cell division; Fungal prion; Mechanism (biology); Cell; Cell biology; Yeast; Genetics; Saccharomyces cerevisiae; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003794461,0.0002813653,0.0003197003,0.0003927592,0.0002760063,0.0005465015,0.0003927559,0.0006588949,0.0004922624],"category_scores_gemma":[0.0009605931,0.0002257295,0.0001678287,0.0003294484,0.0004281727,0.0006811961,0.0003770388,0.0007869536,0.0002201006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004757056,"about_ca_system_score_gemma":0.0002766618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000737895,"about_ca_topic_score_gemma":0.0004896974,"domain_scores_codex":[0.9997358,0.00002384724,0.00001638214,0.00008389076,0.000100833,0.00003932807],"domain_scores_gemma":[0.9995087,0.0002071168,0.0001065531,0.00006298125,0.00006666625,0.00004797378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006479664,0.00007966871,0.005264645,0.00007271179,0.00001252587,0.00008477608,0.00012316,0.003010209,0.984165,0.001051485,0.00007988288,0.005991244],"study_design_scores_gemma":[0.00001654826,0.0003280366,0.01374324,0.0000201244,0.00002162388,0.0002470527,0.0001285573,0.08497268,0.8978815,0.001581458,0.001033149,0.00002601623],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9762859,0.0006290628,0.02179218,0.00008068306,0.00002303884,0.00002209336,0.0001351212,0.0001311912,0.0009007627],"genre_scores_gemma":[0.9892197,0.0003953958,0.009869749,0.00002956531,0.000005735412,0.0000245392,0.00007186657,0.00001466406,0.0003687333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000737895,"threshold_uncertainty_score":0.003451467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0235981812940203,"score_gpt":0.2210009712669069,"score_spread":0.1974027899728866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}