{"id":"W4315778133","doi":"10.1007/s11095-022-03464-y","title":"Prediction of the Renal Organic Anion Transporter 1 (OAT1)- Mediated Drug Interactions for LY404039, the Active Metabolite of Pomaglumetad Methionil","year":2023,"lang":"en","type":"article","venue":"Pharmaceutical Research","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"Eli Lilly and Company","keywords":"Probenecid; Physiologically based pharmacokinetic modelling; Pharmacology; Chemistry; Pharmacokinetics; Organic anion transporter 1; Active metabolite; Prodrug; Renal physiology; Renal function; Metabolite; Transporter; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007268646,0.0006899544,0.0009112674,0.0009764596,0.0003197637,0.0008243879,0.0003805174,0.0008014205,0.002845034],"category_scores_gemma":[0.001621755,0.0001631054,0.0015249,0.000587651,0.0001449182,0.0003064987,0.0002934397,0.0006147956,0.0009896174],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006122814,"about_ca_system_score_gemma":0.0006604647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002509336,"about_ca_topic_score_gemma":0.00317967,"domain_scores_codex":[0.9994676,0.0001411538,0.00004682667,0.0001285414,0.0001600844,0.00005586718],"domain_scores_gemma":[0.9989272,0.0005029864,0.0003109182,0.00003111755,0.0001194472,0.0001083188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01644466,0.001180702,0.6762505,0.0009533581,0.003425995,0.005678181,0.0001207784,0.03792135,0.1353303,0.001119011,0.01072747,0.1108478],"study_design_scores_gemma":[0.002087206,0.00537791,0.3724937,0.0001588949,0.005269053,0.01229865,0.0002644811,0.5019224,0.07909797,0.002151708,0.01869746,0.0001806],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868863,0.002733927,0.003611827,0.0005478592,0.00005417414,0.00006317618,0.004324489,0.0003538019,0.001424584],"genre_scores_gemma":[0.9922709,0.0003244328,0.00244172,0.0001543594,0.00002713597,0.00001563006,0.004300005,0.00003334949,0.0004324059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002845034,"threshold_uncertainty_score":0.00951761,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2071999022809482,"score_gpt":0.4489336531871499,"score_spread":0.2417337509062017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}