{"id":"W4315778310","doi":"10.1021/acs.joc.2c02155","title":"One-Pot Sequential Hydroamination Protocol for N-Heterocycle Synthesis: One Method To Access Five Different Classes of Tri-Substituted Pyridines","year":2023,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Catalytic C–H Functionalization Methods","field":"Chemistry","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs","keywords":"Hydroamination; Pyridine; Chemistry; Combinatorial chemistry; Reaction conditions; Functional group; Yield (engineering); Compatibility (geochemistry); Organic chemistry; Catalysis; Materials science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001986581,0.000764712,0.000379775,0.000329341,0.000350965,0.0001896046,0.0007481431,0.0004174031,0.003523377],"category_scores_gemma":[0.0001550419,0.0002923473,0.0003431091,0.0002454757,0.0002947836,0.0005210122,0.0006601586,0.0009286715,0.001712255],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002900997,"about_ca_system_score_gemma":0.0005286882,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005182447,"about_ca_topic_score_gemma":0.001679927,"domain_scores_codex":[0.9998168,0.00001747711,0.00001783494,0.00006026881,0.00004266059,0.00004485585],"domain_scores_gemma":[0.9999305,0.000009684353,0.00001713232,0.00001740169,0.00001158899,0.00001363006],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001599615,0.0001730175,0.000173395,0.0007888795,0.00005642566,0.0007842848,0.0001853793,0.0009053195,0.9480554,0.002370272,0.00182557,0.04452208],"study_design_scores_gemma":[0.00005589287,0.0009181497,0.0007234762,0.00003183313,0.000035147,0.00166152,0.00004768704,0.001214718,0.9657277,0.000507122,0.02902278,0.0000540632],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.5818354,0.0148618,0.3334118,0.0007198059,0.0006215894,0.001436877,0.002853269,0.002460021,0.06179946],"genre_scores_gemma":[0.9097547,0.007773269,0.06654742,0.0003075873,0.00005518345,0.0006366936,0.001199701,0.0001645671,0.0135608],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.003523377,"threshold_uncertainty_score":0.01178688,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0862278469958648,"score_gpt":0.3838193309805597,"score_spread":0.2975914839846949,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}