{"id":"W4315778614","doi":"10.1101/2023.01.11.23284254","title":"Garetosmab, an inhibitor of activin A, reduces heterotopic ossification and flare-ups in adults with fibrodysplasia ossificans progressiva: a randomized, double-blind, placebo-controlled phase 2 trial","year":2023,"lang":"en","type":"preprint","venue":"medRxiv","topic":"Heterotopic Ossification and Related Conditions","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University Health Network","funders":"Regeneron Pharmaceuticals; University of Pennsylvania; Vanderbilt University Medical Center; Vanderbilt University","keywords":"Fibrodysplasia ossificans progressiva; Placebo; Medicine; Clinical endpoint; Tolerability; Adverse effect; Heterotopic ossification; Internal medicine; Randomized controlled trial; Surgery; Urology; Gastroenterology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001175145,0.001478385,0.002540994,0.0004546612,0.000329105,0.0008350048,0.0007478252,0.001892059,0.004578326],"category_scores_gemma":[0.001127701,0.0006361484,0.001811474,0.0003248751,0.0006163386,0.000810302,0.0002580704,0.002342002,0.0006256152],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004118551,"about_ca_system_score_gemma":0.0006451421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005431263,"about_ca_topic_score_gemma":0.001199207,"domain_scores_codex":[0.9996259,0.0001746212,0.00003090235,0.00007082097,0.00003346322,0.0000642518],"domain_scores_gemma":[0.9993566,0.000200951,0.000148356,0.00003019293,0.00005411212,0.0002098529],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.956659,0.009259341,0.0006816077,0.001413652,0.001251132,0.00007262976,0.00004509044,0.0002694128,0.00594538,0.00007413171,0.0008524148,0.0234761],"study_design_scores_gemma":[0.9245498,0.07215888,0.00175375,0.00004834885,0.0003856911,0.00004359951,0.00001640243,0.0002283493,0.0003419218,0.00004898754,0.0004152393,0.000009087027],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733117,0.01806355,0.0005753027,0.0007043192,0.0005419669,0.003610658,0.001130127,0.0001523241,0.001910064],"genre_scores_gemma":[0.9822964,0.00738303,0.001302885,0.001235204,0.0005768575,0.004140973,0.0009981468,0.00001795906,0.002048645],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004578326,"threshold_uncertainty_score":0.01531601,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05090562283686747,"score_gpt":0.3499890616480531,"score_spread":0.2990834388111857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}