{"id":"W4315780383","doi":"10.1021/acsmedchemlett.2c00502","title":"Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Ontario Institute for Cancer Research; University of Toronto; Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"BCL6; Lymphoma; Virtual screening; Repressor; Cancer research; Diffuse large B-cell lymphoma; Bioavailability; Chemistry; Pharmacology; Medicine; Transcription factor; B cell; Internal medicine; Drug discovery; Immunology; Gene; Biochemistry; Germinal center","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001483654,0.000228754,0.0004152422,0.00007166255,0.00005972927,0.00001950314,0.00008752041,0.000094875,0.00002197799],"category_scores_gemma":[0.0001463238,0.0001786249,0.00008213043,0.0004046847,0.000232319,0.0001022299,0.00007762884,0.0001442745,0.00001914804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001343996,"about_ca_system_score_gemma":0.0001240565,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002159329,"about_ca_topic_score_gemma":0.000002927626,"domain_scores_codex":[0.9985399,0.000009932244,0.0002978184,0.0003974854,0.0004141869,0.0003406832],"domain_scores_gemma":[0.9991864,0.0001069968,0.0002004687,0.0002802286,0.00006541002,0.0001604796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001532963,0.0002227297,0.05948394,0.0004068391,0.0001991527,0.000282009,0.0001682547,0.000001240034,0.9152852,0.000006340205,0.02302174,0.0007693091],"study_design_scores_gemma":[0.004510395,0.0002014601,0.05633923,0.0005203813,0.0003133523,0.0002894284,0.0003397068,0.00002461606,0.9353869,0.00001033731,0.001861208,0.0002030146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894223,0.0003504912,0.00001251503,0.008789183,0.00009189964,0.0001983467,0.00003268831,0.00007426101,0.00102838],"genre_scores_gemma":[0.9969562,0.0002135527,0.0001536855,0.001363435,0.0003327224,0.00003655929,0.0001175274,0.0000260226,0.0008002566],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02116054,"threshold_uncertainty_score":0.7284114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282295859836576,"score_gpt":0.241864561289426,"score_spread":0.2290416026910602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}