{"id":"W4315780383","doi":"10.1021/acsmedchemlett.2c00502","title":"Discovery of OICR12694: A Novel, Potent, Selective, and Orally Bioavailable BCL6 BTB Inhibitor","year":2023,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; Ontario Institute for Cancer Research","funders":"Leslie Dan Faculty of Pharmacy, University of Toronto; Ontario Institute for Cancer Research; University of Toronto; Ontario Ministry of Research and Innovation; Ontario Ministry of Research, Innovation and Science","keywords":"BCL6; Lymphoma; Virtual screening; Repressor; Cancer research; Diffuse large B-cell lymphoma; Bioavailability; Chemistry; Pharmacology; Medicine; Transcription factor; B cell; Internal medicine; Drug discovery; Immunology; Gene; Biochemistry; Germinal center","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001464183,0.0005620541,0.0005865177,0.0005250091,0.0001603277,0.0004701696,0.000557056,0.0003881158,0.001493547],"category_scores_gemma":[0.0001840053,0.0001723818,0.0002697568,0.0004040647,0.0001827341,0.0002389184,0.0003014679,0.001029679,0.0007027519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003998596,"about_ca_system_score_gemma":0.0004404131,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009655999,"about_ca_topic_score_gemma":0.002149481,"domain_scores_codex":[0.9999115,0.000009891743,0.000004961137,0.00001598522,0.00003234065,0.00002529942],"domain_scores_gemma":[0.9999608,0.000003052755,0.000007600746,0.000002950407,0.000007385291,0.00001824784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001440005,0.001000248,0.0009445108,0.000845543,0.0001117052,0.001251383,0.00009192487,0.004188375,0.8156833,0.002201608,0.009313724,0.1629276],"study_design_scores_gemma":[0.00509106,0.01497032,0.009113751,0.0001856729,0.0004391031,0.00699547,0.0001061923,0.01291009,0.8098294,0.0009240927,0.1392982,0.0001366936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9125137,0.02873087,0.02590108,0.002450229,0.0004251998,0.001490448,0.004812738,0.001354791,0.02232089],"genre_scores_gemma":[0.9439313,0.02065038,0.01352405,0.0008466708,0.00007502436,0.0003186726,0.006857916,0.00006237849,0.01373364],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001493547,"threshold_uncertainty_score":0.004996419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01282295859836576,"score_gpt":0.241864561289426,"score_spread":0.2290416026910602,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}