{"id":"W4315780417","doi":"10.1038/s41467-023-35789-6","title":"Oncogenic mutations of PIK3CA lead to increased membrane recruitment driven by reorientation of the ABD, p85 and C-terminus","year":2023,"lang":"en","type":"article","venue":"Nature Communications","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":80,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; University of Victoria","funders":"Michael Smith Health Research BC; Cancer Research Society","keywords":"P110α; PI3K/AKT/mTOR pathway; Mutant; C-terminus; Protein subunit; Mutation; N-terminus; Cell biology; Chemistry; Biology; Biochemistry; Signal transduction; Peptide sequence; Gene; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009443163,0.0003092578,0.0001605685,0.000178513,0.0001578809,0.0002113085,0.0001217321,0.0002271319,0.001051266],"category_scores_gemma":[0.00008748481,0.0001583088,0.0002161027,0.0002115773,0.0003080804,0.0001216972,0.000291234,0.0003709493,0.0002137936],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004989072,"about_ca_system_score_gemma":0.0002305392,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008165619,"about_ca_topic_score_gemma":0.001223366,"domain_scores_codex":[0.999869,0.00001642992,0.00001590621,0.00002494668,0.0000414558,0.00003226371],"domain_scores_gemma":[0.9999264,0.000009563914,0.00002975673,0.000009326414,0.000003200951,0.00002162562],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007089121,0.00001024037,0.0002054591,0.00001170648,0.000004279489,0.00007653218,0.000004162905,0.00006709202,0.9987717,0.0001042312,0.00003436835,0.0006393543],"study_design_scores_gemma":[0.00001782419,0.0001478679,0.00412682,0.000001818983,0.000009900069,0.0006135143,0.00001279443,0.0007172107,0.9927476,0.00007313522,0.001526188,0.000005254559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967203,0.000269577,0.001448287,0.0000782063,0.00003131101,0.00001270995,0.0002462261,0.0001396719,0.001053855],"genre_scores_gemma":[0.9981294,0.0001324852,0.0008820043,0.00002852165,0.000003261019,0.000009882441,0.0001326421,0.00001389007,0.0006680061],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001051266,"threshold_uncertainty_score":0.00361985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03077168993836518,"score_gpt":0.3434084007258515,"score_spread":0.3126367107874863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}