{"id":"W4315780755","doi":"10.1136/jitc-2022-006136","title":"Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors","year":2023,"lang":"en","type":"article","venue":"Journal for ImmunoTherapy of Cancer","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Ottawa Mental Health Centre","funders":"","keywords":"Medicine; Nivolumab; Internal medicine; Oncology; Pharmacodynamics; Colorectal cancer; Response Evaluation Criteria in Solid Tumors; Cohort; Pancreatic cancer; Gastroenterology; Cancer; Phases of clinical research; Pharmacokinetics; Clinical trial; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000759039,0.0002347883,0.0008545719,0.000515376,0.0001061113,0.00003014027,0.0002518916,0.00005742766,0.00008178996],"category_scores_gemma":[0.00002919578,0.0001765568,0.00003752013,0.0005017949,0.000185567,0.0005287247,0.0000283786,0.0002228595,5.426902e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001295936,"about_ca_system_score_gemma":0.0003504238,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00421078,"about_ca_topic_score_gemma":0.002497838,"domain_scores_codex":[0.9980342,0.0004345265,0.0008564376,0.0002304233,0.0001155638,0.0003287955],"domain_scores_gemma":[0.9984062,0.0002235705,0.0009501598,0.000171303,0.0002271797,0.00002156253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04721486,0.003739477,0.06381855,0.0001849205,0.001238551,0.00001306633,0.014022,0.0002695241,0.865537,0.00001328217,0.00001182131,0.00393691],"study_design_scores_gemma":[0.1132854,0.02133493,0.106608,0.0009645722,0.0002914683,0.00006329171,0.01085905,0.0006019982,0.7454869,0.00006736198,0.0000932937,0.0003436876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925736,0.005327567,0.00003930967,0.00004300868,0.0001189495,0.001814524,0.00007188795,0.000007349657,0.000003862378],"genre_scores_gemma":[0.998571,0.0007023118,0.0002463806,0.00001918858,0.000005794478,0.0002658868,0.00002276707,0.00004609927,0.0001205437],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1200501,"threshold_uncertainty_score":0.7199777,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03232948702170655,"score_gpt":0.3487401860462075,"score_spread":0.3164106990245009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}