{"id":"W4315781575","doi":"10.3390/molecules28020757","title":"Small Molecule Drugs That Inhibit Phagocytosis","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Canadian Blood Services; University of Toronto","funders":"Canadian Blood Services","keywords":"Phagocytosis; In vivo; Small molecule; Pyrazole; In vitro; Toxicity; Chemistry; Isoxazole; IC50; Pharmacology; Biochemistry; Biology; Stereochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00005651663,0.0001615626,0.0002430414,0.0001464851,0.00007325469,0.0000226405,0.00006790546,0.00007340107,0.00009019779],"category_scores_gemma":[0.00002263979,0.0001367748,0.0001207145,0.0003308266,0.00003888956,0.00003181217,0.00005899922,0.00008944664,0.001075535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003189816,"about_ca_system_score_gemma":0.00003590253,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006248635,"about_ca_topic_score_gemma":0.00001040644,"domain_scores_codex":[0.999063,0.00001776336,0.0001206496,0.0002673071,0.0002091799,0.0003220576],"domain_scores_gemma":[0.9995454,0.00002545976,0.00003381607,0.0002411497,0.00002806213,0.0001261078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001599656,0.004458292,0.1008922,0.001077668,0.003827373,0.05474412,0.008826619,0.0001264158,0.3719398,0.005893885,0.1838606,0.2627534],"study_design_scores_gemma":[0.01203151,0.0008597815,0.044519,0.0003176001,0.0006415581,0.0003866515,0.001646511,0.00178856,0.9082534,0.003843493,0.02468798,0.001023915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706872,0.0003912818,0.00007443717,0.001667881,0.00006971392,0.0002347002,0.00001567884,0.000290568,0.02656858],"genre_scores_gemma":[0.993992,0.0001724447,0.0003252217,0.00116092,0.00002642365,0.00004492034,0.0001650287,0.00003861143,0.004074451],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5363137,"threshold_uncertainty_score":0.9997022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317100532243894,"score_gpt":0.2629313211226548,"score_spread":0.2297603158002159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}