{"id":"W4315781575","doi":"10.3390/molecules28020757","title":"Small Molecule Drugs That Inhibit Phagocytosis","year":2023,"lang":"en","type":"article","venue":"Molecules","topic":"Platelet Disorders and Treatments","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Canadian Blood Services; University of Toronto","funders":"Canadian Blood Services","keywords":"Phagocytosis; In vivo; Small molecule; Pyrazole; In vitro; Toxicity; Chemistry; Isoxazole; IC50; Pharmacology; Biochemistry; Biology; Stereochemistry; Cell biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002629714,0.0005021249,0.0004730792,0.0005052856,0.0002270196,0.0003840394,0.0002717442,0.0004128707,0.002235723],"category_scores_gemma":[0.000226915,0.0001569282,0.0003587151,0.0002676203,0.0002529508,0.0002640105,0.0003536715,0.0008272144,0.0009521315],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002893244,"about_ca_system_score_gemma":0.000243001,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003390829,"about_ca_topic_score_gemma":0.0008306907,"domain_scores_codex":[0.9998436,0.0000297311,0.00001107792,0.00002493635,0.00005659608,0.0000340624],"domain_scores_gemma":[0.9999126,0.00003018399,0.00001529419,0.000009629421,0.00001749042,0.00001473416],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000409737,0.0005107202,0.0004882211,0.0009189431,0.0000527478,0.000543021,0.00007946766,0.0008419537,0.9081104,0.003414851,0.002431723,0.08219824],"study_design_scores_gemma":[0.0005151993,0.008165247,0.003884013,0.000144019,0.0001114686,0.002422393,0.00004632569,0.002239506,0.8726671,0.001264984,0.1084969,0.00004293604],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.680684,0.199584,0.04660204,0.0030046,0.001618643,0.001859478,0.001422627,0.001169676,0.06405487],"genre_scores_gemma":[0.9050937,0.06064503,0.01346165,0.001281568,0.0003096356,0.0005081734,0.0009747217,0.00004762045,0.01767793],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002235723,"threshold_uncertainty_score":0.007479191,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03317100532243894,"score_gpt":0.2629313211226548,"score_spread":0.2297603158002159,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}