{"id":"W4315784229","doi":"10.1097/01.hjh.0000915436.49440.d6","title":"PS-BPB01-6: PROTECTIVE NOX4 EFFECT IN ENDOTHELIAL CELLS INVOLVES ACTIVATION OF TRANSIENT RECEPTOR POTENTIAL MELASTATIN 2 (TRPM2) CATION CHANNEL","year":2023,"lang":"en","type":"article","venue":"Journal of Hypertension","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"NOX4; TRPM2; Transient receptor potential channel; Enos; NOX1; NADPH oxidase; Myograph; Medicine; Endothelium; Reactive oxygen species; Endothelial dysfunction; TRPV4; Oxidative stress; Superoxide; Internal medicine; Endocrinology; Cell biology; Receptor; Nitric oxide; Chemistry; Biochemistry; Biology; Nitric oxide synthase; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002301551,0.0004142735,0.0006065571,0.000173565,0.0002792394,0.000292603,0.0003881027,0.0005142552,0.004723128],"category_scores_gemma":[0.0001452292,0.0001664746,0.0004641159,0.000202169,0.0003309241,0.0004077614,0.0001873387,0.001619802,0.001149986],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002410018,"about_ca_system_score_gemma":0.0003170436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006130978,"about_ca_topic_score_gemma":0.0005915157,"domain_scores_codex":[0.999709,0.00003858008,0.00002712779,0.0000551548,0.00008593268,0.00008422246],"domain_scores_gemma":[0.9998741,0.000009967791,0.00003107661,0.00001353004,0.0000118914,0.00005938458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009380772,0.000239812,0.0001171595,0.0000862571,0.00001181938,0.00006701091,0.00001882143,0.00004526254,0.9965869,0.0001051599,0.0002740199,0.001509747],"study_design_scores_gemma":[0.0002342461,0.00237144,0.005176573,0.00001370399,0.00005741981,0.0004757131,0.00006233337,0.0009451117,0.9850866,0.00009701544,0.005466964,0.00001285591],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880946,0.001668878,0.004413384,0.0006167945,0.0002964378,0.0000993466,0.001571672,0.0003241382,0.002914697],"genre_scores_gemma":[0.986363,0.001495488,0.002790966,0.0002965495,0.00007183125,0.0002039222,0.002196413,0.00007453912,0.006507146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004723128,"threshold_uncertainty_score":0.01580048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02516995990308761,"score_gpt":0.2716440701386083,"score_spread":0.2464741102355207,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}